Evidence map›Paper›PMID 40616268›Full record

ArticlePhysiological reports2025

NOD1 promotes leukocyte clearance and limits inflammation in female mice during obesity-associated acute lung injury.

Rodrigo Rodrigues E Lacerda, Nicole G Barra, Han Fang, Gabriel Forato Anhê, Jonathan D Schertzer

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rodrigo Rodrigues E LacerdaDepartment of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-3094-8540
Nicole G BarraDepartment of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-2605-0845
Han FangDepartment of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-0450-5087
Gabriel Forato AnhêDepartment of Translational Medicine, University of Campinas, Campinas, São Paulo, Brazil.ORCID 0000-0002-7694-8397
Jonathan D SchertzerDepartment of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-1547-5856

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2019/03751-3Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/09365-8Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC) 2020-05707
6 · The paper itself

Abstract

Obesity is associated with metabolic inflammation, which includes changes to innate immune responses relevant to acute lung injury. NOD1 is a cytosolic pattern recognition receptor involved in sensing bacterial peptidoglycan and has been linked to metabolic inflammation. However, its role in obesity-associated acute lung injury, especially in females, remains unclear. Here, we investigated the impact of NOD1 deficiency on pulmonary inflammation in female mice subjected to a high-fat diet and lipopolysaccharide-induced acute lung injury. Compared to wild-type controls, obese Nod1

Indexed as

Acute Lung InjuryLeukocytesNod1 Signaling Adaptor ProteinObesityAnimalsCytokinesDiet, High-FatFemaleInflammationLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutNeutrophilsCytokinesLipopolysaccharidesNod1 protein, mouseNod1 Signaling Adaptor Proteinacute lung injuryinflammationNOD1obesity

Identifiers

PMID40616268
PMCPMC12227658

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.