Evidence map›Paper›PMID 40616260›Full record

Trial reportJournal of the American Geriatrics Society2025

Nutritional Impairment and Quality of Life Trajectories Among Older Adults With Advanced Cancer.

Surbhi Singhal, Ying Wang, Richard F Dunne, Lee Kehoe, Michael B Sohn, Marielle Jensen-Battaglia, Beverly Canin, Rachael Tylock, Mostafa Mohamed, Jamil Khatri and 4 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02107443 (Improving Communication for Cancer Treatment), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02107443 nacompletednot on this map

Improving Communication for Cancer Treatment: Addressing Concerns of Older Cancer Patients and Caregivers

TypeinterventionalSponsorSupriya MohileRan2014 to 2020Enrolled546ConditionsAdult Solid Neoplasm, LymphomaArmsGeriatric Assessment Summary, Geriatric Assessment Targeted Recommendations, Geriatric Assessment (GA)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Surbhi SinghalDivision of Hematology/Oncology, Department of Medicine, University of California Davis, California, USA.
Ying WangDepartment of Public Health Sciences, University of Rochester Medical Center, New York, USA.ORCID https://orcid.org/0000-0002-2317-8915
Richard F DunneDivision of Hematology and Oncology, James P. Wilmot Cancer Institute, University of Rochester Medical Center, New York, USA.
Lee KehoeDivision of Supportive Care in Cancer, Department of Surgery, James P. Wilmot Cancer Institute, University of Rochester Medical Center, New York, USA.
Michael B SohnDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Marielle Jensen-BattagliaDepartment of Public Health Sciences, University of Rochester Medical Center, New York, USA.ORCID https://orcid.org/0000-0003-1941-9218
Beverly CaninStakeholders for Care in Oncology and Research for Our Elders (SCOREBoard) Advisory Committee, California, USA.
Rachael TylockDivision of Hematology and Oncology, James P. Wilmot Cancer Institute, University of Rochester Medical Center, New York, USA.ORCID https://orcid.org/0000-0002-5348-4470
Mostafa MohamedDepartment of Public Health Sciences, University of Rochester Medical Center, New York, USA.
Jamil KhatriDelaware/Christiana Care NCI Community Oncology Research Program (NCORP), Delaware, USA.
James BeardenSoutheast Clinical Oncology Research Consortium NCORP, Spartanburg, South Carolina, USA.
Tony PhilipNorthwell Health Cancer Institute, New York, USA.ORCID https://orcid.org/0000-0001-6014-1292
Supriya MohileDivision of Hematology and Oncology, James P. Wilmot Cancer Institute, University of Rochester Medical Center, New York, USA.
Kah Poh LohDivision of Hematology and Oncology, James P. Wilmot Cancer Institute, University of Rochester Medical Center, New York, USA.

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
UC Davis Paul Calabresi K12 Clinical Oncology Research Career Development ProgramK12CA138464 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BIRKELAND, ANDREW CHARLES, LARA, PRIMO N. · 2011 to 2025
$11.4M
Geriatric Oncology Research Infrastructure to Improve Clinical CareR33AG059206 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI WILLIAM DALE, Heidi Diana Klepin · 2020 to 2026
$5.1M
A Patient-Oriented Research Program in Geriatric OncologyK24AG056589 · NIA · UNIVERSITY OF ROCHESTER · PI Supriya G. Mohile · 2018 to 2026
$1.5M
A novel mobile health exercise intervention for older patients with myeloid neoplasmsR00CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2021 to 2023
$747k
Epigenetic markers, functional status, and exercise in older adults with myeloid neoplasmsR03AG073985 · NIA · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2022 to 2023
$308k
Aging in place for older adults with cancer: The role of physical function and home environmentF99CA284180 · NCI · UNIVERSITY OF ROCHESTER · PI JENSEN-BATTAGLIA, MARIELLE · 2023 to 2024
$95k
Conquer Cancer FoundationNCI NIH HHS F99 CA284180NCI NIH HHS K12 CA138464NCI NIH HHS R00 CA237744NCI NIH HHS UG1 CA189961NIA NIH HHS K24 AG056589NIA NIH HHS R03 AG073985NIA NIH HHS R33 AG059206NIH HHS F99CA284180NIH HHS K12CA138464NIH HHS K24AG056589NIH HHS R00CA237744NIH HHS R03AG073985NIH HHS R33AG059206NIH HHS UG1CA189961Patient-Centered Outcomes Research Institute Contract 4634Walther Cancer FoundationWilmot Research Fellowship Award
6 · The paper itself

Abstract

backgroundNutritional impairment is common among older adults with advanced cancer. The association between baseline nutritional impairment and the trajectory of quality of life (QOL) and psychological health among patients receiving palliative cancer treatment is not known.

methodsWe performed a secondary analysis of a nationwide clinical trial (NCT02107443; PI: Mohile, UG1CA189961). Adults aged

resultsAmong 479 patients, mean age was 77 (range 70-93) and 56% had nutritional impairment. We identified four QOL trajectories and four psychological health trajectories. Nutritional impairment was associated with group membership in Lowest (odds ratio [OR] 4.2, 95% confidence interval [CI] 2.0-8.9), Middle-Low (OR 3.8, 95% CI 2.1-6.9), and Middle-High QOL (OR 2.4, 95% CI 1.4-4.2), compared to Highest QOL. For depression, nutritional impairment was associated with membership in Worsening Mild Depression group (OR 3.7, 95% CI 1.8-7.5), compared to No Depression group.

conclusionsBaseline nutritional impairment was independently associated with membership in every worse QOL trajectory group and with membership in the "Worsening Mild Depression" group. This is the first study, to our knowledge, to examine the association between baseline nutritional impairment and QOL and psychological health trajectory among patients with cancer. Integrating early nutritional assessment with paired supportive care is important for older adults with advanced cancer.

Indexed as

MalnutritionNeoplasmsQuality of LifeAgedAged, 80 and overDepressionFemaleGeriatric AssessmentHumansMaleNutritional StatusNutrition AssessmentPalliative Careadvanced cancernutritional impairmentpsychological healthquality of life

Identifiers

PMID40616260
PMCPMC12236448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.