ArticleCardio-oncology (London, England)2025
QT STAR: concomitant QTc-prolonging medication use among patients with HR+/HER2- metastatic breast cancer receiving a CDK4/6 inhibitor in first line.
Article in Cardio-oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Integrated care for long-responder women with metastatic breast cancer: Expert opinion for long term management in spain].Atencion primaria · 2026Guideline
- The mechanisms and therapeutic advances of interactions between breast cancer and cardiovascular diseases.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe risk of drug-induced corrected QT interval (QTc) prolongation is an important consideration in clinical decision-making for patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer (mBC). This retrospective analysis described concomitant QTc-prolonging medication use in patients with HR+/HER2- mBC who received first-line (1L) treatment with a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) plus an aromatase inhibitor (AI).
methodsThis retrospective claims analysis utilized the Optum Clinformatics Data Mart database to identify patients with HR+/HER2- mBC who initiated 1L CDK4/6i plus AI treatment between January 2017 and March 2022. Exposure to QTc-prolonging medications (overall and by Torsades de Pointes [TdP] risk, per www.crediblemeds.org ) was assessed at index (i.e., CDK4/6i treatment initiation) and during follow-up (i.e., duration of CDK4/6i treatment) in the overall cohort and cohorts stratified by patient age.
resultsA total of 1517 patients met the study criteria; 33.8%, 35.5%, and 30.8% were aged < 65, 65-74, and ≥ 75 years, respectively. Exposure to ≥ 1 QTc-prolonging medication or ≥ 1 medication with known TdP risk was observed in 53.3% and 15.4% of patients at index, respectively, and 78.6% and 57.1% of patients during follow-up, respectively. Patients were exposed to QTc-prolonging medications for 54.6% of total person-time during follow-up. Patients aged ≥ 65 years had higher exposure to medications with conditional TdP risk than those aged < 65 years, primarily driven by increased diuretic use.
conclusionsQTc-prolonging medication use was common in patients with HR+/HER2- mBC receiving 1L CDK4/6i plus AI treatment, highlighting the importance of reviewing concomitant medications to inform CDK4/6i selection and patient monitoring while on treatment.
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