ArticleBMC pediatrics2025
Lymphangiomatosis with pulmonary, mediastinal, and spinal involvement in a pediatric patient: a case report.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLymphangiomatosis is a rare disorder characterized by abnormal proliferation and dilation of lymphatic vessels, resulting in non-specific clinical manifestations. This report describes the case of an 8-year-old male patient with lymphangiomatosis involving the lungs, mediastinum, and spine, with the objective of promoting awareness and understanding of this condition. CASE PRESENTATION: An 8-year-old male patient presented with chest tightness. Two years ago, the patient underwent decortication of the pleural fibrous plate due to empyema. Within two months after the operation, the patient successively developed chylothorax and chylopericardium. Chest CT revealed thickening of the interlobular septa and peribronchovascular interstitial tissue in both lungs. Spinal MRI showed scoliosis in the cervicothoracic region, flattening of several vertebral bodies, and multiple osteolytic lesions. Pathological examination of mucosal tissue obtained from the basal segment of the left lower lobe of the lung via bronchoscopy confirmed a diagnosis of lymphangiomatosis. The patient’s condition improved significantly after three weeks of treatment with sirolimus and bevacizumab, with marked alleviation of the chest tightness symptoms during the 23-month follow-up period.
conclusionLymphangiomatosis is associated with indolent progression and non-specific clinical/radiological features, frequently manifesting as multiorgan involvement. Diagnostic suspicion should arise when chylous effusions coexist with osteolytic lesions, although histopathological verification remains the gold standard. Although there is no current consensus on therapeutic strategies, emerging pharmacological interventions including the use of sirolimus, bevacizumab, propranolol, interferon-α, and tyrosine kinase inhibitors, which demonstrate variable efficacy. This case underscores the importance of multidisciplinary collaboration in the management of complex lymphatic malformations and indicates the potential of targeted therapies in pediatric patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.