ArticleBMC anesthesiology2025
Effects of intraperitoneal magnesium sulfate on perioperative inflammatory response in rats with pneumoperitoneum.
Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Correlation between hemoglobin-to-albumin ratio and complications after radical gastrectomy in gastric cancer patients.Frontiers in medicine · 2025Article
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4 authors.
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Abstract
backgroundLaparoscopy, while minimally invasive, leads to local and systemic inflammatory responses due to pneumoperitoneum. Recent studies highlight the anti-inflammatory effects of magnesium and its deficiency's link to inflammation. This study aimed to investigate the dose-dependent local and systemic anti-inflammatory effects of Mg
methodsThirty-six rats were divided into four groups: MG250, MG500, pneumoperitoneum group (PG), and control group (CG). PG, MG250, and MG500 underwent pneumoperitoneum for 60 min at 12 mmHg. MG250 and MG500 received 250 mg/kg and 500 mg/kg of i.p. MgSO4 respectively, while PG received 0.9% saline. No additional procedures were performed on CG. Serum and peritoneal tissue samples were collected from all groups. Tissue samples were examined for inflammatory cell infiltration, congestion, and cellularoedema. Systemic inflammation was evaluated by measuring TNF-α, IL-1, IL-10, and MPO levels in serum samples.
resultsComparisons between CG and PG revealed that pneumoperitoneum amplified the local inflammatory response. Regarding systemic markers, only MPO levels were higher in PG compared to CG (p < 0.001). In MG250, both histopathological findings and MPO levels showed a lower inflammatory response compared to PG. No significant differences were observed between MG500 and PG.
conclusionsThe application of i.p. MgSO4 during the perioperative period may exhibit anti-inflammatory effects at an appropriate dose. However, further large-scale, prospective, and randomized studies are necessary to better understand the local and systemic effects of Mg CLINICAL TRIAL NUMBER: Not applicable.
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