ArticleBMC musculoskeletal disorders2025
Correlation between iron accumulation and sarcopenia in middle-aged and elderly populations.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Prospective Associations of Serum Vitamin B12, Homocysteine, and Ferritin Levels with Probable Sarcopenia.Nutrients · 2026Article
- Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?Aging cell · 2026Review
- The Potential Role of Iron Homeostasis and Ferroptosis in Exercise Nutrition and Health.Nutrients · 2026Review
- Targeting Aging and Diseases Associated with Ferroptosis and Senescence Through Modulation of Iron, Oxidative Stress and Lipid Peroxidation.Antioxidants (Basel, Switzerland) · 2025Review
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Authors and funding
4 authors.
Funding
Abstract
purposeThe goal of this study was to investigate the relationship between iron accumulation and sarcopenia risk.
methodWe conducted a cross-sectional study based on data acquired during the year 2022-2023 from the affiliated hospital of Jiangsu University. Data on age, sex, body mass index (BMI), limb muscle mass, white blood cell (WBC) count, C-reactive protein (CRP) level, serum iron concentration, ferritin level, total iron- binding capacity (TIBC), and transferrin saturation (TSAT) were collected and analyzed. We used t-tests, chi-square tests, binary logistic regression models, and Generalized Additive Models (GAMs) for nonlinear analyses as statistical analyses.
resultsThere were 110 participants, including 44 males and 66 females. Binary logistic regression analysis indicated that serum ferritin level was a risk factor for sarcopenia (OR = 1.005, 95% CI], 1.001, 1.009; P = 0.042. Furthermore, nonlinear analysis suggested a potential U-shaped relationship between ferritin levels and the risk of sarcopenia. Specifically, the risk appeared to decrease at ferritin levels below approximately 226.4 µg/L and increase at levels above approximately 241.2 µg/L. Both the overall nonlinear association (P = 0.033) and the nonlinear effect (P = 0.012) were statistically significant.
conclusionSerum ferritin levels may be an independent risk factor for sarcopenia in the healthy elderly population. Additionally, a non-linear relationship between ferritin levels and the risk of sarcopenia was revealed. Nevertheless, further research is needed to elucidate the complex pathways connecting iron metabolism to muscle health, and to guide the development of targeted interventions for preventing and managing sarcopenia in this population.
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Registered trials
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