SynthesisBMC cardiovascular disorders2025
The impact of continuous positive airway pressure therapy on the recurrence of atrial fibrillation in patients with obstructive sleep apnea after pulmonary vein isolation.
Synthesis in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Documented Obstructive Sleep Apnea, Cardiometabolic Phenotype, and Rhythm-Related Outcomes After Atrial Fibrillation Ablation: An Observational Cohort Study.Journal of arrhythmia · 2026Article
- Review
- Obstructive Sleep Apnoea and Atrial Fibrillation: Current Evidence and Emerging Research Directions.Reviews in cardiovascular medicine · 2026Review
- Impact of obstructive sleep apnea on arrhythmic risk in ischemic heart disease and hypertrophic cardiomyopathy: insights from a large national cohort.Frontiers in cardiovascular medicine · 2026Article
- Unveiling the inflammatory link: integrated analysis identifies BMP7 and PPBP as key genes in obstructive sleep apnea-related atrial fibrillation.Frontiers in cell and developmental biology · 2026Article
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Authors and funding
13 authors.
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Abstract
backgroundWhile obstructive sleep apnea (OSA) is recognized as a risk factor for atrial fibrillation (AF) recurrence following pulmonary vein isolation (PVI), the preventive efficacy of continuous positive airway pressure (CPAP) remains conflicting across studies, necessitating further validation.
methodsWe conducted a meta-analysis integrating data from Web of Science, PubMed, and OVID databases to evaluate the association between OSA and AF recurrence post-PVI, as well as the effect of continuous positive airway pressure (CPAP).
resultsOSA patients demonstrated a significantly elevated risk of AF recurrence compared to controls (RR = 1.67, 95% CI:1.52-1.83). Stratified analyses revealed differential effects based on left atrial (LA) size: OSA patients without significant LA enlargement exhibited an risk ration (RR) of 2.13 (95% CI:1.63-2.79), and those with enlarged LA size showed an RR of 1.78 (95% CI:1.46-2.17). Subgroup stratification by AF type revealed no significant impact of OSA on recurrence in studies with paroxysmal AF only (RR = 1.15, 95% CI:0.74-1.77), whereas an elevated RR of 1.7 (95% CI:1.54-2.11) emerged in studies combining paroxysmal and persistent AF populations. CPAP therapy reduced AF recurrence risk overall (RR = 0.6, 95% CI:0.52-0.70), but this benefit varied by LA size comparability (no LA difference: RR = 0.58, 95% CI:0.33-1.01; significant LA difference: RR = 0.61, 95% CI:0.49-0.76). CPAP efficacy was evident in mixed AF populations (RR = 0.56, 95% CI:0.48-0.67) but absent in paroxysmal AF cohorts (RR = 1.3, 95% CI:0.71-1.50).
conclusionThis meta-analysis confirms that OSA is an independent predictor of AF recurrence following PVI. While CPAP therapy confers a general protective benefit, it does not have an effect in patients with paroxysmal AF or in those without left atrial enlargement. These results highlight the necessity of phenotypic stratification when designing and implementing CPAP-based preventive strategies.
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