ReviewMolecular neurobiology2025
Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation.
Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Preliminary study of polyethylene microplastics disrupting energy Metabolism, redox Balance, and prefrontal cortex structure in Wistar rats.Scientific reports · 2026Article
- Micro- and nanoplastic exposure as an emerging risk factor for depressive-like phenotypes across species: a systematic review.Frontiers in toxicology · 2026Review
- Polylactic acid microplastics as metabolic disruptors: Linking gut dysbiosis to systemic toxicity by disrupting microbiota-host co-metabolism.Current research in toxicology · 2026Review
- Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects.Toxics · 2025Review
- Oxidative genomic or genotoxic stress in neurodegeneration: Mechanisms and therapeutic avenues.AIMS neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The widespread production of plastic in all daily appliances and its poor non-biodegradable characteristics along with toxic plasticizers pose significant risks to human health, leading to several life-threatening conditions, including neurological illnesses, cardiovascular diseases, and cancer. Microplastics (MPs) (101 nm-5 mm) and nanoplastics (NPs) (≤ 100 nm) infiltrate the human body via the respiratory system, digestive tract, and dermal absorption, resulting in the alteration of numerous biological and cellular processes, including apoptosis, endoplasmic reticulum stress, DNA damage, oxidative stress, and inflammation, among others. The bioaccumulation of MPs and NPs disrupts the gut-brain axis, resulting in memory impairment, synapse malfunction, and ultimately cognitive deficits. Therefore, it is crucial to comprehend the molecular mechanisms by which MPs and NPs disrupt cellular function to assess their hazards to human health. This review explores the formation, behavior, toxicity, pollution, and health effects of MPs and NPs, while highlighting research gaps to encourage further studies on their unique properties and biological interactions. This review further elucidates the detrimental impact of MPs and NPs on the development and progression of neurological illnesses, as well as management strategies to alleviate the toxic effects of exposure to these substances.
Indexed as
Identifiers
40615763What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.