ReviewBritish journal of cancer2025
Non-melanoma skin cancer and HPV in persons with albinism: a call for research investment.
Review in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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12 authors.
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Abstract
Persons with albinism (PWA) have excessively high risks of non-melanoma skin cancer (NMSC) if not protected from ultraviolet (UV) radiation exposures, a situation which occurs too often amongst affected persons in sub-Saharan Africa. Certain countries in Eastern and Southern Africa, where levels of UV radiation are high, also have amongst the world's highest national-level prevalence of oculocutaneous albinism. Cutaneous HPV infections, particularly β-HPVs, may be co-factors with UV in skin carcinogenesis. If this is the case, there may be a pivotal potential for NMSC risk reduction via suitable vaccine development in all at-risk populations, and with the greatest individual-level benefit in PWA. With this background, and amidst climate change-induced increases in UV exposures, the research funding and scientific community are urged to prioritise HPV research on skin carcinogenesis in PWA. In the current perspective, we summarise: (1) the putative co-role of HPV with UV in skin carcinogenesis; (2) the possible implications of a potential HPV role in NMSC carcinogenesis; (3) the risks of skin cancer in PWA in the African setting; and (4) the research needs on HPV and NMSC in PWA, including the sensitivities and ethical responsibilities of undertaking such research amongst the PWA community in the African context.
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