Evidence map›Paper›PMID 40615699›Full record

SynthesisEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025

The neuroprotective role of riluzole in spinal cord injury: a systematic review and meta-analysis.

Hamed Zarei, Seyedhesamoddin Khatami, Mohammadsadegh Faghihi, Kimia Bagheri, Hannanehsadat Khatami, Haniyeh Ghorbanibaroogh, Amirmohammad Toloui, Hamzah Adel Ramawad, Mahmoud Yousefifard

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hamed Zarei *Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Seyedhesamoddin Khatami *Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Mohammadsadegh FaghihiPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Kimia BagheriPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Hannanehsadat KhatamiPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Haniyeh GhorbanibarooghPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Amirmohammad TolouiPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Hamzah Adel RamawadDepartment of Pain Medicine, Ochsner Clinic Foundation, New Orleans, LA, USA.
Mahmoud YousefifardPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran. yousefifard20@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We systematically reviewed the evidence for the efficacy of riluzole on functional recovery and lesion size following spinal cord injury (SCI). The search was conducted on Medline, Embase, Scopus, and Web of Science by November 2024 for studies evaluating the utility of riluzole administration following SCI in rodents and humans. Neurological and histopathological outcomes were extracted for subjects treated and not treated with Riluzole. Pooled effect estimates were calculated using the random-effects model. Heterogeneity was assessed using the I

Indexed as

Neuroprotective AgentsRiluzoleSpinal Cord InjuriesAnimalsHumansLocomotionRecovery of FunctionNeuroprotective AgentsRiluzoleRiluzoleSpinal cord injuryTrauma

Identifiers

PMID40615699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.