Evidence map›Paper›PMID 40615656›Full record

Observational studyInternational urology and nephrology2025

Correlation between thyroid function and proteinuria in patients with chronic kidney disease stages 3 and 4.

Karina Schiavoni Scandelai, Pietra Desiree Bourdon Fuentes Azevedo Vianna, João Pedro Barbosa Sanches, Rachel Bregman, Ana Beatriz Winter Tavares

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04658524 (Evaluation of Thyroid Function in Patients With Chronic Kidney Disease), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04658524 unknown statusnot on this map

Evaluation of Thyroid Function in Patients With Chronic Kidney Disease

TypeobservationalSponsorRio de Janeiro State UniversityRan2018 to 2025Enrolled44ConditionsChronic Kidney Disease, Thyroid DysfunctionArmsThyroid function
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Karina Schiavoni ScandelaiPostgraduate Program in Clinical and Experimental Physiopathology (Fisclinex), Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0003-4060-7803
Pietra Desiree Bourdon Fuentes Azevedo ViannaFaculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0009-0001-9266-7800
João Pedro Barbosa SanchesFaculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0003-2351-7160
Rachel BregmanNephrology Service, Department of Internal Medicine- Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0002-4794-3327
Ana Beatriz Winter TavaresPostgraduate Program in Clinical and Experimental Physiopathology (Fisclinex), Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. anabeatrizwinter@yahoo.com.br.ORCID http://orcid.org/0000-0002-6653-246X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeProteinuria in the nephrotic range is associated with loss of thyroxine-binding protein, levothyroxine, or both, which may lead to subclinical hypothyroidism. The aim of this study was to correlate thyroid function and proteinuria in patients with stages 3 and 4 chronic kidney disease (CKD), in addition to evaluating whether thyroid function differs in these stages of CKD.

methodsObservational, cross-sectional study including 150 patients with stages 3 and 4 CKD. Thyroid stimulating hormone (TSH), free T4 (FT4) and the urine protein-creatinine ratio (PCR) were analyzed. Proteinuria was defined as ≥ 200 mg/g.

resultsSixty-four patients (42.6%) had stage 3 CKD, and 86 patients (59.4%) had stage 4 CKD. The median age was 68 years (IQR 61-76), the median TSH was 2.9 µIU/mL (IQR 1.89-4.04), the median FT4 was 1.26 ng/dL (IQR 1.10-1.41), and the median PCR was 315.5 mg/g (IQR 108.3-830). Ninety-one patients (60.6%) had proteinuria. In the total sample and in CKD stage 3, there was a statistically significant positive correlation between PCR and TSH, and a negative correlation between PCR and FT4. There were significant differences in the median age (p = 0.004), estimated glomerular filtration rate (p = 0.002), TSH (p = 0.001) and FT4 (p = 0.05) between the PCR < and ≥ 200 mg/g groups.

conclusionThe results demonstrated a significant correlation between thyroid function and PCR, which corroborates that urinary protein loss can alter thyroid function in CKD stages 3 and 4. Thyroid function did not differ between CKD stages 3 and 4. STUDY DATASET IS AVAILABLE ON CLINICALTRIALS. GOV ID: NCT04658524.

Indexed as

ProteinuriaRenal Insufficiency, ChronicThyroid GlandAgedCreatinineCross-Sectional StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexThyroid Function TestsThyrotropinThyroxineCreatinineThyrotropinThyroxineChronic kidney insufficiencyProteinuriaThyroid diseasesThyroid function tests

Identifiers

PMID40615656

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