Evidence map›Paper›PMID 40615597›Full record

Observational studySurgery today2025

Outcomes of patients with clinical stage IV esophageal squamous cell carcinoma treated initially with definitive chemoradiotherapy: a single-institution observational study and literature review.

Kotaro Sugawara, Koichi Yagi, Shoh Yajima, Yoshiyuki Miwa, Shuichiro Oya, Asami Okamoto, Raito Asaoka, Hideomi Yamashita, Yoshifumi Baba

Abstract readObservational StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kotaro SugawaraDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. mayotic@hotmail.com.ORCID http://orcid.org/0000-0002-3272-1748
Koichi YagiDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Shoh YajimaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Yoshiyuki MiwaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Shuichiro OyaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Asami OkamotoDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Raito AsaokaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Hideomi YamashitaDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshifumi BabaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the long-term outcomes of patients with cStage IV esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (dCRT) and the impacts of this treatment on inflammatory and nutrition markers.

methodsThe subjects of this study were 84 patients who underwent initial dCRT for cStage IV (cT4 and/or cM1 according to eighth UICC staging system) esophageal squamous cell carcinoma (ESCC). Survival outcomes were investigated according to treatment modalities. Various inflammatory and nutrition markers, such as the C-reactive protein (CRP)-to-albumin ratio (CAR) and the lymphocyte-to-CRP ratio (LCR), were evaluated.

resultsThe 3-year overall survival (OS) rate of the 84 patients was 45.8%. Clinical complete response (CR) to dCRT was achieved in 30 patients (dCRT-CR group). Salvage surgery was performed for 35 patients and curative (R0) resection was achieved in 28 patients (surg-R0 group). Patients in the surg-R0 group exhibited comparable 3-year OS (60.7%) to patients in the dCRT-CR group (60.0%). CRP-derived markers (LCR and CAR) were significantly associated with the response to dCRT (both P < 0.01) and OS (both P < 0.01).

conclusionsDefinitive chemoradiotherapy is appropriate for patients with cStage IV ESCC. Curative salvage surgery provides survival benefits for the tumor entity. Pre-therapeutic CRP-derived markers are useful for predicting the response to dCRT and long-term outcomes.

Indexed as

Carcinoma, Squamous CellChemoradiotherapyEsophageal NeoplasmsAdultAgedAged, 80 and overBiomarkersBiomarkers, TumorC-Reactive ProteinEsophageal Squamous Cell CarcinomaFemaleHumansMaleMiddle AgedNeoplasm StagingSalvage TherapyBiomarkersBiomarkers, TumorC-Reactive ProteinClinical stage IVDefinitive chemoradiotherapyEsophageal squamous cell carcinomaSalvage surgery

Identifiers

PMID40615597
PMCPMC12602661

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.