ArticleScientific reports2025
Expression of urinary exosomal miR-136-5p in diabetic kidney disease and evaluation of its clinical diagnostic value.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic value of urinary exosomes in patients with IgA nephropathy and diabetic kidney disease: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Sex differences in urinary extracellular vesicles originating from the genitourinary system in health and disease.American journal of physiology. Renal physiology · 2026Review
- Exosome-Mediated Systemic Signaling: Mechanisms, Disease Integration, and Translational Potential.Current issues in molecular biology · 2026Review
- Urinary Extracellular Vesicle-Derived miRNAs as Regulators and Biomarkers in Diabetic Kidney Disease.International journal of molecular sciences · 2026Review
- Review
- Urinary Extracellular Vesicles Biomarkers in CKD: Clinical Laboratory Translation.Diagnostics (Basel, Switzerland) · 2026Review
- Extracellular Vesicle-Derived MicroRNAs as Early Diagnostic Biomarkers of Diabetic Nephropathy and Cardiovascular Diseases in Type 2 Diabetes.International journal of molecular sciences · 2026Review
- Urinary exosomes aggravate diabetic kidney disease by inducing podocyte ferroptosis via the miR-217/SIRT1/Nrf2 pathway.Journal of cell communication and signaling · 2026Article
- Emerging Urinary Biomarkers and Innovative Technologies for the Early Detection and Personalized Management of Chronic Kidney Disease.International journal of molecular sciences · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
Diabetic kidney disease (DKD) has become a major cause of chronic kidney disease and end-stage renal disease. Numerous studies have indicated that exosomal miRNAs play a crucial role in the pathophysiological processes of DKD. We screened differentially expressed miRNAs in urinary exosomes from patients with DKD using the GEO database and performed PCR validation both in patients who were pathologically diagnosed and clinically diagnosed. We assessed the clinical diagnostic value of urinary exosomal miRNAs using ROC curves, analyzed the correlation between miRNAs and clinical indicators, predicted the target genes using the miRTarBase database and explored the potential signaling pathways involved through functional enrichment analysis. Screening results showed that the expression of miR-136-5p was significantly elevated in the DKD group compared to the DM group, with significance maintained in validation samples. The sensitivity and specificity of miR-136-5p for diagnosing DKD were 72.2% and 78.4%, respectively, with an area under the curve of 0.722. Additionally, the expression of miR-136-5p was positively correlated with UACR, urea nitrogen, cystatin C, chronic kidney disease progression risk stratification indicators, and negatively correlated with eGFR. 152 target genes of miR-136-5p were predicted and enriched in 25 pathways, including insulin secretion, cAMP signaling pathway, and sphingolipid signaling pathway.
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