Evidence map›Paper›PMID 40615433›Full record

ArticleScientific reports2025

An international multi-cohort investigation of self-reported sleep and future depressive symptoms in older adults.

Meredith L Wallace, Nina Oryshkewych, Sanne J W Hoepel, Daniel J Buysse, Lucas Mentch, Meryl A Butters, Katie L Stone, Kristine Yaffe, Lisa L Barnes, Andrew S Lim and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Meredith L WallaceDepartment of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. lotzmj@upmc.edu.
Nina OryshkewychUniversity of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Sanne J W HoepelDepartment of Epidemiology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
Daniel J BuysseDepartment of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.
Lucas MentchDepartment of Statistics, University of Pittsburgh, Pittsburgh, PA, USA.
Meryl A ButtersDepartment of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.
Katie L StoneCalifornia Pacific Medical Center, San Francisco, CA, USA.
Kristine YaffeDepartments of Psychiatry and Behavioral Sciences, Neurology and Epidemiology, University of California at San Francisco, San Francisco, CA, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Andrew S LimDepartment of Neurology, University of Toronto, Toronto, ON, Canada.
Kristine E EnsrudDivision of Epidemiology and Community Health and Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Misti L PaudelDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Annemarie LuikRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7517-197X

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Study of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2M
Risk Factors for Cognitive Decline in African-AmericansR01AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2004 to 2025
$18.2M
Long term fracture risk and change in peripheral bone in the oldest old men: The MrOS studyR01AG066671 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI BOUXSEIN, MARY L, CAWTHON, PEGGY MANNEN · 2020 to 2024
$13.3M
Outcomes of Sleep Disorders in Older MenR01HL071194 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI STONE, KATIE L · 2003 to 2013
$12.2M
Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3M
Changes in Sleep and Cognition in Older WomenR01AG026720 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STONE, KATIE L, YAFFE, KRISTINE · 2006 to 2016
$7.5M
Study of Osteoporotic FracturesR01AG005394 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1986 to 2015
$6.1M
Osteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
Sleep Quality and Mechanistic Links to Alzheimer Disease and Related Disorders among older Mexican Americans and Non-Hispanic WhitesR01AG066137 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'BRYANT, SID E, YAFFE, KRISTINE · 2019 to 2023
$4.3M
NCATS NIH HHS UL1 TR002369NHLBI NIH HHS R01 HL070837NHLBI NIH HHS R01 HL070838NHLBI NIH HHS R01 HL070839NHLBI NIH HHS R01 HL070841NHLBI NIH HHS R01 HL070842NHLBI NIH HHS R01 HL070847NHLBI NIH HHS R01 HL070848NHLBI NIH HHS R01 HL071194NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIAMS NIH HHS U01 AR066160NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG026720NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS R01 AG066137NIA NIH HHS R01 AG066671NIA NIH HHS RF1 AG056331NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168
6 · The paper itself

Abstract

Poor subjective sleep is associated with future depression in older adults, but there is limited consensus on which sleep features have the strongest associations. Moreover, composite scores incorporating multiple features may better represent sleep burden than individual sleep items. We analyzed older adults (age ≥ 60) without clinically relevant depressive symptoms from a multi-cohort United States sample (US; N = 4826) and the Netherlands' Rotterdam Study (RS; N = 3663), with the goal of identifying individual and composite sleep features that are associated with future clinically relevant depressive symptoms 3-6 years later. Sleep-related daytime symptoms (Risk Ratio [95% CI] 2.10 [1.58, 2.80] in US; 2.10 [1.40, 3.14] in RS) and difficulty falling asleep (1.87 [1.49, 2.35] in US; RS = 1.90 [1.50, 2.43] in RS) were the strongest individual sleep features. Moreover, the combination of these features was most impactful (3.32 [2.33, 4.73] in US; 3.19 [2.64, 3.86] in RS), providing the largest effect size with the fewest number of items. Future studies should assess whether screening tools incorporating these features, paired with targeted sleep treatment, could reduce rates of incident depression in older adults. Examining mechanisms underlying these associations could improve the effectiveness of sleep-related treatments in older adults.

Indexed as

DepressionSleepSleep Wake DisordersAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedNetherlandsRisk FactorsSelf ReportUnited StatesAgingDepressionHarmonizationInsomniaSleep health

Identifiers

PMID40615433
PMCPMC12227749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.