Evidence map›Paper›PMID 40615413›Full record

ArticleNature communications2025

Shared genetic architecture between eating disorders, mental health conditions, and cardiometabolic diseases: a comprehensive population-wide study across two countries.

Joeri Meijsen, Kejia Hu, Dang Wei, Stefana Aicoboaie, Helena L Davies, Ruyue Zhang, Mischa Lundberg, Richard Zetterberg, Joëlle Pasman, Weimin Ye and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Joeri Meijsen *Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Mental Health Services Copenhagen, Roskilde, Denmark. joeri.jeroen.meijsen@regionh.dk.ORCID http://orcid.org/0000-0002-4161-2199
Kejia Hu *Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6680-8107
Dang WeiUnit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1287-7929
Stefana AicoboaieInstitute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Mental Health Services Copenhagen, Roskilde, Denmark.
Helena L DaviesInstitute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Mental Health Services Copenhagen, Roskilde, Denmark.
Ruyue ZhangDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mischa LundbergInstitute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Mental Health Services Copenhagen, Roskilde, Denmark.
Richard ZetterbergInstitute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Mental Health Services Copenhagen, Roskilde, Denmark.ORCID http://orcid.org/0000-0002-4284-4063
Joëlle PasmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Weimin YeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-6859-4648
Thomas WergeInstitute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Mental Health Services Copenhagen, Roskilde, Denmark.ORCID http://orcid.org/0000-0003-1829-0766
Cynthia M BulikDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7772-3264
Fang FangUnit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-3310-6456
Alfonso BuilInstitute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Mental Health Services Copenhagen, Roskilde, Denmark.ORCID http://orcid.org/0000-0002-3097-1014
Nadia MicaliInstitute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Mental Health Services Copenhagen, Roskilde, Denmark. nadia.micali@regionh.dk.ORCID http://orcid.org/0000-0001-5571-2273

Funding

Eating Disorders Genetics Initiative (EDGI)R01MH120170 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2019 to 2023
$7.2M
1/3 Eating Disorders Genetics Initiative 2 (EDGI2)R01MH136149 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CYNTHIA M BULIK, Laura Marianne Huckins · 2024 to 2026
$5.1M
A Trans-Nordic Study of Extreme Major DepressionR01MH123724 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PATRICK F SULLIVAN, Lu Yi · 2020 to 2026
$4.7M
Predicting the multi-omic impact of psychiatric GWAS associationsR01MH118278 · NIMH · YALE UNIVERSITY · PI HUCKINS, LAURA MARIANNE · 2019 to 2023
$3.6M
1/7 PGC: Advancing Discovery and ImpactR01MH124871 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, SULLIVAN, PATRICK F · 2021 to 2025
$3.5M
Predicting Binge and Purge Episodes from Passive and Active Apple Watch Data Using a Dynamical Systems ApproachR01MH119084 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, BUTNER, JONATHAN · 2019 to 2022
$2.8M
Genetic Architecture of Avoidant/Restrictive Food Intake DisorderR56MH129437 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, MICALI, NADIA · 2022 to 2023
$1.5M
NIMH NIH HHS R01 MH118278NIMH NIH HHS R01 MH119084NIMH NIH HHS R01 MH120170NIMH NIH HHS R01 MH123724NIMH NIH HHS R01 MH124871NIMH NIH HHS R01 MH136149NIMH NIH HHS R56 MH129437
6 · The paper itself

Abstract

Eating disorders arise from a complex interaction of genetic and environmental influences. Here we provide comprehensive population-level estimates of the heritability of eating disorders and their genetic relationships with various mental health and cardiometabolic disorders (CMDs), expanding beyond genome-wide association studies. We examined the heritability of three eating disorders-anorexia nervosa (AN), bulimia nervosa (BN), and other eating disorders (OED)-and investigated shared familial and genetic risk factors with mental health disorders and CMDs. Using national register data from Denmark and Sweden (1972-2016), we analysed clinical diagnoses for over 67,000 individuals with eating disorders, their first-degree relatives, and matched controls from populations totalling 17 million. Heritability estimates were moderate, h

Indexed as

Cardiovascular DiseasesFeeding and Eating DisordersMental DisordersMental HealthMetabolic DiseasesAdolescentAdultAnorexia NervosaBulimia NervosaDenmarkFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle Aged

Identifiers

PMID40615413
PMCPMC12227696

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.