ArticleThe Journal of international medical research2025
Correlation analysis of systemic immune-inflammation index values and arthritis risk in adults.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveTo investigate the correlation between systemic immune-inflammation index (SII) values and the risk of arthritis among adult participants.MethodsCross-sectional data from adult participants (aged ≥18 years) in the National Health and Nutrition Examination Survey 2011-2018 dataset were utilized. The association between systemic immune-inflammation index values and arthritis risk was explored through multivariate regression and restricted cubic spline model-based analyses.ResultsAn analysis of categorical variables indicated that the risk of arthritis was significantly higher in the highest systemic immune-inflammation index quartile (Q4) compared with the lowest quartile (Q1; odds ratio = 1.36, 95% confidence interval = 1.23-1.51). Continuous variable and spline model analyses suggested that there was a significant and positive correlation between high systemic immune-inflammation index values and an increased risk of arthritis (odds ratio = 1.12, 95% confidence interval = 1.08-1.16, p < 0.001). A subgroup analysis revealed that this correlation was stronger in the older population than in the younger population (p interaction = 0.041). A sensitivity analysis suggested that the association between systemic immune-inflammation index values and arthritis risk was stable.ConclusionsOur research suggests a correlation between high systemic immune-inflammation index values and an increased risk of arthritis within the examined sample. Consequently, tracking systemic immune-inflammation index values could potentially facilitate the early detection of arthritis.
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