ArticleJACC. Case reports2025
Giant Cell Myocarditis Presenting With Cardiogenic Shock: Diagnostic and Therapeutic Challenges.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Giant cell myocarditis: from immune pathogenesis to contemporary management.Heart failure reviews · 2026Review
- Giant cell myocarditis in a middle-aged male: features in CMR.The international journal of cardiovascular imaging · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giant cell myocarditis (GCM) is a rare but often fatal inflammatory cardiomyopathy characterized by aggressive myocardial inflammation and necrosis. Prompt recognition and immunosuppressive therapy are critical for improving outcomes. A 48-year-old woman with no prior cardiac history presented with dyspnea, orthopnea, and hypotension. Electrocardiography showed wide complex tachycardia with retrograde V-to-A conduction. Laboratory findings revealed rising high-sensitivity troponin, hepatic injury, and leukocytosis. Echocardiography showed biventricular failure, and cardiac magnetic resonance imaging showed myocardial edema and subepicardial enhancement. Endomyocardial biopsy confirmed GCM. Immunosuppressive therapy with corticosteroids, tacrolimus, and mycophenolate mofetil led to clinical improvement, avoiding transplantation. GCM remains a diagnostic and therapeutic challenge due to its rapid progression and arrhythmic burden. This case highlights the importance of early biopsy, tailored immunosuppression, and vigilant monitoring in managing fulminant myocarditis.
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