Evidence map›Paper›PMID 40614930›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2025

Global assessment of partial artemisinin resistance: multicenter trial across Kenya, Peru, and Thailand in patients with uncomplicated Plasmodium falciparum malaria.

Ben Andagalu, Edward Smith, Salomon Durand, Hugo O Valdivia, Irene Onyango, Michele Spring, Vanachayangkul Pattaraporn, G Christian Baldeviano, Elazia Majid, Sabaithip Sriwichai and 30 more

Abstract readMulticenter Study
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Ben AndagaluU.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Edward SmithUniversidad Peruana Cayetano Heredia, Lima, Peru.
Salomon DurandU.S. Naval Medical Research Unit SOUTH, Lima, Peru.
Hugo O ValdiviaU.S. Naval Medical Research Unit SOUTH, Lima, Peru. Electronic address: hugo.o.valdivia.ln@health.mil.
Irene OnyangoU.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Michele SpringWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Vanachayangkul PattarapornWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
G Christian BaldevianoU.S. Naval Medical Research Unit SOUTH, Lima, Peru.
Elazia MajidU.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Sabaithip SriwichaiWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
James CummingsArmed Forces Health Surveillance Division, Silver Spring, United States of America.
Lorena TapiaU.S. Naval Medical Research Unit SOUTH, Lima, Peru.
Hosea AkalaU.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Panita GosiWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Cesar CabezasInstituto Nacional de Salud-INS, Lima, Peru.
Dennis JumaU.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Saowaluk WongararunkochakornWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Moises SihuinchaHospital César Garayar, Iquitos, Peru.
Chaiyaporn ChaisatitWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Lorna Chebon-BoreU.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Worachet KuntawunginnWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Alaina HalbachArmed Forces Health Surveillance Division, Silver Spring, United States of America.
Chanikarn KodchakornWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Chatchadaporn ThamnurakWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Chantida PraditpolWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Piyaporn SaingamWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Kimberly A EdgelU.S. Naval Medical Research Unit SOUTH, Lima, Peru.
David SaundersU.S. Army Medical Materiel Development Activity, Fort Detrick, United States of America.
Agnes CheruiyotU.S. Army Medical Research Directorate-Africa, Nairobi, Kenya.
Ilin ChuangNaval Medical Research Command, Silver Spring, United States of America.
Ekaterina MilgotinaGlobal Scientific Solutions for Health, Baltimore, United States of America.
Paula FernandesGlobal Scientific Solutions for Health, Baltimore, United States of America.
Andres G LescanoUniversidad Peruana Cayetano Heredia, Lima, Peru; U.S. Naval Medical Research Unit SOUTH, Lima, Peru.
Nonlawat BoonyalaiWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Edwin KamauDepartment of Pathology and Area Laboratory Service, Tripler Army Medical Center, Honolulu, United States of America.
Brett M ForsheyArmed Forces Health Surveillance Division, Silver Spring, United States of America.
Stephanie CinkovichArmed Forces Health Surveillance Division, Silver Spring, United States of America; Cherokee Nation Strategic Programs, Tulsa, United States of America.
Delia BethellWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Krisada JongsakulWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.
Mark FukudaWRAIR-AFRIMS Armed Forces Research Institute of Medical Sciences Bangkok, Bangkok, Thailand.

Funding

Peru Infectious Diseases Epidemiology Research Training ConsortiumD43TW007393 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI Andres G Lescano · 2005 to 2026
$5.9M
FIC NIH HHS D43 TW007393
6 · The paper itself

Abstract

objectivesArtemisinin-resistant Plasmodium falciparum challenges the effectiveness of all artemisinin-based combination therapies.

methodsWe conducted a clinical study in Peru, Kenya, and Thailand between June 2013 and November 2015 in subjects treated with three standard doses of artesunate followed by two doses of mefloquine. The primary endpoint was parasite clearance half-life (PC

resultsThe mean PC

conclusionsThis is the first concurrent evaluation of artemisinin resistance across three continents. The presence of 11% Thai subjects who satisfied WHO criteria for drug resistance establishes this area as endemic. Longer PC

Indexed as

AntimalarialsArtemisininsDrug ResistanceMalaria, FalciparumPlasmodium falciparumAdolescentAdultArtesunateChildChild, PreschoolFemaleHumansKenyaMaleMefloquineMiddle AgedAntimalarialsArtemisininsArtesunateMefloquineProtozoan ProteinsArtemisininK13 mutationsMalariaResistance

Identifiers

PMID40614930
PMCPMC12410058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.