Evidence map›Paper›PMID 40614870›Full record

ArticleTheoretical population biology2025

The TMRCA of general genealogies in populations with deterministically varying size.

Alejandro H Wences, Lizbeth Peñaloza, Matthias Steinrücken, Arno Siri-Jégousse

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theoretical population biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Alejandro H WencesLAAS - CNRS, Université de Toulouse, 7 av. du colonel Roche, BP 54200, 31031 Toulouse, cedex 4, France.
Lizbeth PeñalozaInstituto de Investigación de Matemáticas y Actuaría, Universidad del Mar, Campus Huatulco, Carretera Federal No 200, Km 250, 70989 Santa María Huatulco, Oaxaca, Mexico.
Matthias SteinrückenDepartment of Ecology and Evolution, University of Chicago, 1101 E. 57th St., 60637, Illinois, USA; Department of Human Genetics, University of Chicago, 928 E. 58th St., 60637, Illinois, USA. Electronic address: steinrue@uchicago.edu.
Arno Siri-JégousseInstituto de Investigaciones en Matemáticas Aplicadas y Sistemas, Universidad Nacional Autónoma de México, CU 04510 CDMX, Mexico. Electronic address: arno@sigma.iimas.unam.mx.

Funding

Population genetic methods to detect population structure and adaptation using modern and ancient genomic datasetsR01GM146051 · NIGMS · UNIVERSITY OF CHICAGO · PI Matthias Steinruecken · 2022 to 2026
$1.7M
NIGMS NIH HHS R01 GM146051
6 · The paper itself

Abstract

We study the time to the most recent common ancestor (TMRCA) of a sample of finite size in a wide class of genealogical models for populations with deterministically varying size. This is made possible by recently developed results on inhomogeneous phase-type random variables, allowing us to obtain the density and the moments of the TMRCA of time-dependent coalescent processes in terms of matrix formulas. We also provide matrix simplifications permitting a more straightforward calculation. With these results, the TMRCA provides an explanatory variable to distinguish different evolutionary scenarios, and to infer model parameters.

Indexed as

Genetics, PopulationModels, GeneticHumansPopulation DensityCoalescent theoryPhase-type theoryVariable size population

Identifiers

PMID40614870
PMCPMC12331193

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.