Evidence map›Paper›PMID 40614733›Full record

ArticleStem cell reports2025

Disruption of normal stem cell function and transmission of myelodysplastic syndrome by self-renewal of committed myeloid lineage cells.

Yang Jo Chung, Ryan Bertoli, Dengchao Cao, Robert L Walker, Yuelin Jack Zhu, Paul Meltzer, Peter D Aplan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yang Jo ChungGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Ryan BertoliGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Dengchao CaoGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Robert L WalkerGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Yuelin Jack ZhuGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Paul MeltzerGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Peter D AplanGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Myeloid Malignancies Program, National Institutes of Health, Bethesda, MD, USA. Electronic address: aplanp@mail.nih.gov.

Funding

Activation of Proto-Oncogenes--Chromosomal TranslocationZ01SC010378 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI APLAN, PETER D · 2001 to 2008
$1.5M
Pre-clinical Studies of Therapy for Myelodysplastic SyndromeZ01BC010983 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APLAN, PETER · 2008 to 2008
$344k
Intramural NIH HHS Z01 BC010983Intramural NIH HHS Z01 SC010378
6 · The paper itself

Abstract

The ineffective hematopoiesis of myelodysplastic syndrome (MDS) suggests that hematopoietic stem and progenitor cells (HSPCs) are defective. Here, we demonstrate that NUP98::HOXD13 (NHD13) MDS mice have significantly decreased functional HSPCs. Moreover, in contrast to wild-type (WT) bone marrow (BM), lineage-positive (Lin

Indexed as

Cell LineageCell Self RenewalHematopoietic Stem CellsMyelodysplastic SyndromesMyeloid CellsAnimalsCell ProliferationHematopoiesisHomeodomain ProteinsMiceMice, Inbred C57BLNuclear Pore Complex ProteinsProto-Oncogene Proteins c-kitTranscription FactorsHomeodomain ProteinsHoxd13 protein, mousenuclear pore complex protein 98Nuclear Pore Complex ProteinsProto-Oncogene Proteins c-kitTranscription FactorshematopoiesiskitMDS-initiating cellmyelodysplastic syndromeNHD13stem cells

Identifiers

PMID40614733
PMCPMC12365822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.