The association between cardiac vagal activity and urinary catecholamine: Investigating the effect of race and sex.

Li Shen Chong, Betty Lin, Elana B Gordis, DeWayne P Williams, Julian F Thayer

Abstract read

In one paragraph

Article in Psychoneuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li Shen ChongDepartment of Psychology, San José State University, One Washington Square, San José, CA 95192-0120, United States. Electronic address: jess.chong@sjsu.edu.

Betty LinDepartment of Psychology, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY 12222, United States. Electronic address: blin6@albany.edu.

Elana B GordisDepartment of Psychology, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY 12222, United States. Electronic address: egordis@albany.edu.

DeWayne P WilliamsDepartment of Psychological Science, University of California, Irvine, 4201 Social & Behavioral Sciences Gateway, Irvine, CA 92697-7085, United States. Electronic address: dewaynpw@uci.edu.

Julian F ThayerDepartment of Psychological Science, University of California, Irvine, 4201 Social & Behavioral Sciences Gateway, Irvine, CA 92697-7085, United States; Department of Psychology, Ohio State University, Psychology Building, 225, 1835 Neil Ave, Columbus, OH 43210, United States. Electronic address: jfthayer@uci.edu.

Funding

Intra- and Intergenerational Consequences of Maternal Stress Exposure for Maternal-Infant Health in Black U.S. FamiliesR01HD106913 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Betty Lin · 2022 to 2026

$3.0M

NICHD NIH HHS R01 HD106913

6 · The paper itself

Abstract

Black individuals are at greater risk for the development of cardiovascular diseases compared to White individuals. Autonomic nervous system (ANS) dysregulation has been identified as a significant risk factor contributing to racial disparities in cardiovascular disease, yet systematic racial differences that affect the measurement of ANS activity among White and Black participants are likely obscuring understanding about ANS-health disparity links. Moreover, sex differences in ANS activity have been observed. Thus, efforts to elucidate the comparability of ANS indices across race and sex are needed. This study aimed to investigate the effects of race and sex on the associations between two indices of ANS activity-cardiac vagal activity and urinary catecholamines-in a sample of White and Black participants from the MIDUS 2: Biomarker Project (N = 967 adults aged 34 - 84; 81 % White, 57 % female). Participants self-reported their sociodemographic and health information and completed biomarker assessments. Cardiac vagal activity was assessed via heart rate (HR) and heart rate variability (HRV); urinary catecholamines were assessed via epinephrine and norepinephrine. Black participants displayed higher HRV activity and lower levels of urinary catecholamines relative to White participants. Moreover, our results revealed small but significant correlations between urinary catecholamines and cardiac vagal activity across both races, though the nature of these relations varied across race, sex, and ANS index. The correlations between HR and epinephrine and norepinephrine were stronger among Black male participants compared to White male participants. Our results highlight the importance of clarifying the functional equivalence of different ANS indices across race and sex.

Indexed as

CatecholaminesVagus NerveAdultAgedAged, 80 and overAutonomic Nervous SystemBiomarkersBlack or African AmericanBlack PeopleCardiovascular DiseasesEpinephrineFemaleHeartHeart RateHumansMaleBiomarkersCatecholaminesEpinephrineNorepinephrineCardiac vagal activityEpinephrineHeart rate variabilityNorepinephrineRaceSex

Identifiers

PMID40614395

DOI10.1016/j.psyneuen.2025.107527

PMCPMC13138854

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LicenceCC BY-NC

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.