ArticleAddictive behaviors2025
Sleep disruption, stress, and craving during inpatient treatment for opioid use disorder.
Article in Addictive behaviors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Blunted light exposure amplitudes in patients with opioid use disorder.Npj biological timing and sleep · 2026Article
- Acute and persistent sex-dependent disruptions of sleep-wake architecture induced by fentanyl self-administration in mice.Neuropharmacology · 2026Article
- Smartphone-Based Ecological Momentary Assessment to Monitor Opioid Use and Overdose Among People Who Use Opioids: Prospective Observational Feasibility Study.JMIR human factors · 2026Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThere is a bidirectional relationship between sleep disturbances and opioid misuse, and individuals with opioid use disorder (OUD) often experience poor sleep and insomnia. We aimed to characterize the relationship between sleep, craving, and negative affect among individuals with OUD seeking inpatient detoxification.
methodsAdults receiving inpatient stabilization and detoxification treatment for OUD (N = 84) completed self-report measures of sleep and a standardized stress induction (the Computerized Mirror-Tracing Persistence Task) and rated their opioid craving and negative affect pre- and post-stressor. We examined whether sleep in the prior night and past two-week insomnia were associated with emotional stress reactivity and stress-induced craving.
resultsParticipants reported high levels of insomnia in the prior two weeks and shorter than recommended prior night sleep duration. There were no significant associations between sleep characteristics and baseline craving and pre-stressor negative affect. Greater insomnia severity in the past two weeks was associated with greater stress-induced craving and negative affect, past-night sleep duration was not. DISCUSSION: Insomnia over a two-week period, but not past-night sleep, was associated with increased craving and negative affect following stress, suggesting that disturbed sleep may be an important risk factor in early recovery. Replication and extension with objective measures of sleep will be needed to better understand these associations and their impact on relapse and recovery.
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