Evidence map›Paper›PMID 40614190›Full record

ArticleScience advances2025

Multiomic integration reveals subtype-specific predictors of neoadjuvant treatment response in breast cancer.

Zongchao Mo, Mei Yang, Zhihan Zhu, Minghao Wang, Haoyu Wang, Zhanye Zhang, Shanshan Lyu, Fangping Xu, Haixia Shang, Huan Lin and 7 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  3. Article
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  5. Article
  6. Review
  7. Article
  8. Review
  9. Association of Post-Neoadjuvant Chemotherapy MRI andDiagnostics (Basel, Switzerland) · 2026
    Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zongchao MoDivision of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Hong Kong, SAR, China.ORCID 0009-0006-9678-6600
Mei YangDepartment of Breast Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Zhihan ZhuDivision of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Hong Kong, SAR, China.ORCID 0000-0003-3779-4265
Minghao WangDivision of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Hong Kong, SAR, China.ORCID 0009-0001-1943-1594
Haoyu WangDivision of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Hong Kong, SAR, China.
Zhanye ZhangDivision of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Hong Kong, SAR, China.ORCID 0009-0009-8539-9877
Shanshan LyuDepartment of Pathology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Fangping XuDepartment of Pathology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Haixia ShangDivision of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Hong Kong, SAR, China.ORCID 0000-0002-9765-8145
Huan LinDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.ORCID 0000-0003-4354-6110
Zeyan XuDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.ORCID 0000-0003-1384-3536
Suyun LiDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Xiaobo ChenDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.ORCID 0000-0001-8755-6199
Kun WangDepartment of Breast Cancer, Cancer Centre, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.ORCID 0000-0001-9851-7080
Changhong LiangDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.ORCID 0000-0002-6017-7129
Jiguang WangDivision of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Hong Kong, SAR, China.ORCID 0000-0002-6923-4097
Zaiyi LiuDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.ORCID 0000-0002-9307-8522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neoadjuvant therapy has been widely used in breast cancer, but treatment response varies among individuals. We conducted multiomic profiling on tumor samples from 149 Chinese patients with breast cancer across ER

Indexed as

Breast NeoplasmsNeoadjuvant TherapyBiomarkers, TumorDNA MethylationErb-b2 Receptor Tyrosine KinasesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMachine LearningMiddle AgedPrognosisReceptors, EstrogenTreatment OutcomeBiomarkers, TumorErb-b2 Receptor Tyrosine KinasesReceptors, Estrogen

Identifiers

PMID40614190
PMCPMC12227054

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.