Evidence map›Paper›PMID 40614187›Full record

ArticleScience advances2025

Mitochondrial dysfunction enhances influenza pathogenesis by up-regulating de novo sialic acid biosynthesis.

Amanda L Fuchs, Bharati Singh, Jillian W Jetmore, Emily B Warren, Payal Banerjee, Jose L Marin Franco, Michael A Eckhaus, Tatiana N Tarasenko, Madeleine R Assaad, Ivan Kosik and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amanda L FuchsMetabolism, Infection, and Immunity Section, Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7085-0727
Bharati SinghMetabolism, Infection, and Immunity Section, Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8817-5387
Jillian W JetmoreMetabolism, Infection, and Immunity Section, Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0000-1360-7635
Emily B WarrenMetabolism, Infection, and Immunity Section, Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3561-3478
Payal BanerjeeMetabolism, Infection, and Immunity Section, Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-1599-0679
Jose L Marin FrancoMetabolism, Infection, and Immunity Section, Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Michael A EckhausDivision of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, MD, USA.
Tatiana N TarasenkoMetabolism, Infection, and Immunity Section, Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6560-0985
Madeleine R AssaadMetabolism, Infection, and Immunity Section, Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0003-5437-9124
Ivan KosikCellular Biology Section, National Institute of Allergy and Infectious, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5756-5182
Jonathan YewdellCellular Biology Section, National Institute of Allergy and Infectious, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3826-1906
Peter J McGuireMetabolism, Infection, and Immunity Section, Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5601-3044

Funding

Metabolism, infection and immunity in inborn errors of mitochondrial metabolismZIAHG200381 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI MCGUIRE, PETER · 2012 to 2025
$21.7M
Immunobiology and Virology of Influenza A VirusZIAAI001211 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI YEWDELL, JONATHAN W · 2016 to 2025
$10.4M
Intramural NIH HHS ZIA AI001211Intramural NIH HHS ZIA HG200381
6 · The paper itself

Abstract

Mitochondrial dysfunction can trigger metabolic adaptations that resemble those induced by influenza A virus (IAV) infection. Here, we show that oxidative phosphorylation (OXPHOS) impairment, modeled by

Indexed as

Influenza A virusInfluenza, HumanMitochondriaN-Acetylneuraminic AcidOrthomyxoviridae InfectionsAnimalsDisease Models, AnimalEpithelial CellsHumansLungMiceMice, KnockoutOxidative PhosphorylationVirus ReplicationN-Acetylneuraminic Acid

Identifiers

PMID40614187
PMCPMC12227048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.