ArticlePlant biotechnology journal2025
A novel synergistic regulatory mechanism involving the MYB39-MYB111-bHLH51-TTG1 module in the phenolic and diterpenoid biosynthetic pathways of Salvia miltiorrhiza.
Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The transcription factorHorticulture research · 2026Article
- Multiomics Analysis across the Life Cycle Identifies ZnJournal of agricultural and food chemistry · 2026Article
- bHLH130 mediates gibberellin signaling to regulate tanshinone biosynthesis inActa pharmaceutica Sinica. B · 2026Article
- Recent Advances in Transcription Factor-Mediated Regulation of Salvianolic Acid Biosynthesis inPlants (Basel, Switzerland) · 2026Review
- Hydrogen Sulfide: A Multitarget Therapeutic for Neuroinflammation in Neurodegenerative Diseases.Research (Washington, D.C.) · 2026Review
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Authors and funding
14 authors.
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Abstract
Plants produce a variety of secondary metabolites, and their biosynthesis is often regulated by multiple transcription factors. However, the potential connections between the biosynthesis of different types of metabolites remain unclear. In this study, we present a novel mechanism in which the MYB39-MYB111-bHLH51-TTG1 module synergistically regulates both the phenolic and diterpenoid biosynthetic pathways in the medicinal model plant Salvia miltiorrhiza. SmMYB39 acts as a repressor, while the MYB111-bHLH51-TTG1 (SmMBW) complex functions as an activator of these pathways. SmMYB39 interferes with the formation of the SmMBW complex by interacting with all its components. Additionally, SmMYB39 inhibits the transcriptional activity of SmbHLH51 on its target genes. Expression of SmMYB39 is suppressed by exogenous MeJA, whereas the expressions of SmbHLH51, SmMYB111 and SmTTG1 are induced. Furthermore, SmMYB39 interacts with SmJAZ1, a core repressor in the jasmonic acid (JA) signalling pathway. These findings suggest that the SmMYB39-SmMBW module mediates JA signalling and synergistically regulates the biosynthesis of phenolics and diterpenoids in S. miltiorrhiza. Our findings offer important insights into the coordinated regulatory mechanisms of transcription activators and repressors that control distinct metabolic pathways in plants.
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