Evidence map›Paper›PMID 40614080›Full record

ReviewAnnual review of vision science2025

Development of Retinal Astroglia.

Jeremy N Kay, Juan C Valdez-Lopez, Ekta M Dembla, Adam M Miltner

Abstract readReview
In one paragraph

Review in Annual review of vision science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeremy N KayDepartments of Neurobiology, Ophthalmology, and Cell Biology, Duke University School of Medicine, Durham, North Carolina, USA; email: jeremy.kay@duke.edu.
Juan C Valdez-LopezDepartments of Neurobiology, Ophthalmology, and Cell Biology, Duke University School of Medicine, Durham, North Carolina, USA; email: jeremy.kay@duke.edu.
Ekta M DemblaDepartments of Neurobiology, Ophthalmology, and Cell Biology, Duke University School of Medicine, Durham, North Carolina, USA; email: jeremy.kay@duke.edu.
Adam M MiltnerDepartments of Neurobiology, Ophthalmology, and Cell Biology, Duke University School of Medicine, Durham, North Carolina, USA; email: jeremy.kay@duke.edu.

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Goldis Malek · 1985 to 2026
$19.3M
Mechanisms of naturally-occurring astrocyte death during retinal developmentR01EY030611 · NEI · DUKE UNIVERSITY · PI Jeremy N Kay · 2019 to 2026
$2.7M
Molecular and cellular requirements for Crb1 gene function in the onset and therapeutic rescue of an inherited retinal degenerationR01EY035637 · NEI · DUKE UNIVERSITY · PI Jeremy N Kay · 2024 to 2026
$1.6M
Astrocyte-specific molecular cues guiding retinal angiogenesisF32EY035119 · NEI · DUKE UNIVERSITY · PI VALDEZ-LOPEZ, JUAN · 2023 to 2025
$242k
NEI NIH HHS F32 EY035119NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY030611NEI NIH HHS R01 EY035637
6 · The paper itself

Abstract

Müller cells and retinal nerve fiber layer astrocytes are the major astroglia of the mammalian retina. They have numerous important functions in adulthood for maintaining neuronal homeostasis as well as in developing retina, where they facilitate key events in the assembly of the retinal tissue. Recent years have seen substantial progress in understanding how these astroglial cells develop and how their development shapes the cells around them. We review the mechanisms underlying the formation, maturation, and spatial patterning of Müller glia and retinal astrocytes, with an emphasis on how they acquire their functional properties. We focus on developmental events that have a major impact on overall retinal integrity, such as the formation of neuro-glial junctions at the outer limiting membrane and the patterning of retinal astrocytes into a template that guides angiogenesis. Finally, we discuss examples of retinal diseases that originate in developmental defects affecting Müller cells or retinal astrocytes. These include certain classes of inherited retinal degenerations, as well as retinopathy of prematurity.

Indexed as

AstrocytesEpendymoglial CellsRetinaAnimalsHumansRetinal DegenerationfoveaMüller gliasynapsetilingvasculature

Identifiers

PMID40614080
PMCPMC12450049

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.