ArticleNeurology and therapy2025
The Predictive Value of Heart Rate Variability for the Prognosis of Patients with Mild to Moderate Traumatic Brain Injury.
Article in Neurology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024381 (The Predictive Value of Heart Rate Variability for the Prognosis of Patients With Mild to Moderate Traumatic Brain Injury), which is not on this map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Predictive Value of Heart Rate Variability for the Prognosis of Patients With Mild to Moderate Traumatic Brain Injury
Who cites it
2 citing papers in PubMed.
- Efficacy and safety of Lingbao Huxin Dan in the treatment of sick sinus syndrome: a randomized, single-blind, placebo-controlled, crossover trial.Frontiers in cardiovascular medicine · 2026Trial
- Individualising Neurointensive Care of Traumatic Brain Injury: Reduced Signal Complexity Relates to Secondary Insults and Predicts Worse Outcome.Neurocritical care · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionTraumatic brain injury (TBI) is a major cause of death and disability in adults. After the injury, patients may experience autonomic dysfunction of the heart, making heart rate variability (HRV) an important factor in predicting their prognosis. This study explored the impact of HRV upon admission on the prognosis of patients with TBI.
methodsThis was a retrospective study that collected clinical data from 172 patients with TBI. Unfavorable prognosis was defined as Glasgow Outcome Scale (GOS) scores < 4, the risk factors were investigated using multivariate logistic regression analysis, and a model for unfavorable prognosis was developed. The prediction value of several models was examined by calculating the area under the receiver operating characteristic (ROC) curve.
resultsAmong all 172 patients, those with unfavorable prognosis (31 patients) had a lower standard deviation of normal-to-normal (NN) interval (SDNN) index than those with favorable prognosis (65 vs. 86; P = 0.001). The GCS score (OR 0.295, P < 0.001), hemoglobin (OR 0.957, P = 0.002), CK-MB (OR 1.164, P = 0.022), and SDNN index (OR 0.973, P = 0.010) were identified as independent risk variables for unfavorable prognosis using multivariate logistic regression analysis, and they were utilized to build the prognosis model. The area under the ROC curve of the prognosis model was 0.939 (95% confidence interval, 0.898-0.979).
conclusionHRV can be used as an independent predictor of unfavorable prognosis in patients with TBI. Including the SDNN index in prognostic models helps to effectively predict the prognosis of adult patients with TBI.
trial registrationClinicalTrial.gov Identifier NCT07024381, retrospectively registered 16 June 2025.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.