Evidence map›Paper›PMID 40613964›Full record

ArticleCerebellum (London, England)2025

Detailed Mapping of the Cerebellar Dentate Nucleus Using Ultra-High Field (7T) Susceptibility-Weighted Imaging.

Laura C Rice, Micah R Plotkin, Dylan Parodi, Beatrice Ojuri, Maansi Barnwal, James J Pekar, Catherine J Stoodley, Xu Li, Deana Crocetti, Stewart H Mostofsky

Abstract read
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In one paragraph

Article in Cerebellum (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura C RiceCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 N. Broadway, Baltimore, MD, 21205, USA.
Micah R PlotkinCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 N. Broadway, Baltimore, MD, 21205, USA.
Dylan ParodiCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 N. Broadway, Baltimore, MD, 21205, USA.
Beatrice OjuriCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 N. Broadway, Baltimore, MD, 21205, USA.
Maansi BarnwalCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 N. Broadway, Baltimore, MD, 21205, USA.
James J PekarDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Catherine J StoodleyDeveloping Brain Institute, Children's National Hospital, Washington, DC, 20010, USA.
Xu LiDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Deana CrocettiCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 N. Broadway, Baltimore, MD, 21205, USA.
Stewart H MostofskyCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 716 N. Broadway, Baltimore, MD, 21205, USA. mostofsky@kennedykrieger.org.

Funding

Ultra high-field (7T) in-vivo imaging for detailed characterization of cerebellar dentate nucleus structure and function in children with autismR21MH133012 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2024 to 2025
$417k
NIH HHS 5R21MH133012-02NIMH NIH HHS R21 MH133012
6 · The paper itself

Abstract

The current study presents a novel method for imaging the cerebellar dentate nucleus, combining ultra-high field (7T) and quantitative susceptibility mapping (QSM) to enhance tissue boundary identification and segmentation. After assessing segmentation reliability, we assessed validity by evaluating volume and resting state functional connectivity (FC) of the dorsal vs. ventral dentate subregions. Neurotypical adults (n = 30, 15 females) completed 7T susceptibility-weighted imaging (SWI) and resting state fMRI. QSM maps were used to segment the dentate (whole, dorsal, ventral subregions). Reliability of the segmentation protocol was established across three raters (inter-rater) and one rater who performed the segmentations twice (intra-rater) using the Dice coefficient (d). Dorsal and ventral dentate volumes were calculated, and whole-brain seed-to-voxel FC patterns were assessed from the whole dentate, dorsal, and ventral subregions. Group-level contrasts for each subregion and between subregions were thresholded at voxel-level p <.005, with a cluster-level FDR-correction of p <.05. Segmentation reliability was high (inter-rater d = 0.89, intra-rater d = 0.93), and the dorsal subregion was significantly smaller than the ventral (p <.001). The dorsal dentate showed greater FC with regions involved in sensorimotor processing (cerebellar vermis I-V, IX-X, lobules VIII-IX, fusiform, cuneus), and the ventral dentate showed greater FC with regions involved in cognitive processing (cerebellar lobule VII, angular gyrus, middle and superior frontal gyri, middle and superior temporal gyri, temporal pole). We present an innovative, reliable, and valid method for imaging the dentate. Dentate volumes and FC were consistent with anatomical mapping from animal and human studies. Future directions include application to clinical populations with anomalous cerebellar development and injury.

Indexed as

Brain MappingCerebellar NucleiMagnetic Resonance ImagingAdultFemaleHumansMaleMiddle AgedReproducibility of ResultsYoung AdultCerebellumCerebro-cerebellar circuitsDorsal dentateQuantitative susceptibility mappingResting state fMRIVentral dentate

Identifiers

PMID40613964

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.