Evidence map›Paper›PMID 40613946›Full record

ArticleCerebellum (London, England)2025

Cerebellar Brain Inhibition and Its Association with Motor Inhibition and Reaction Time In Younger and Older Adults.

Shanti Van Malderen, Melina Hehl, Marten Nuyts, Stefanie Verstraelen, Stephan P Swinnen, Koen Cuypers

Abstract read
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In one paragraph

Article in Cerebellum (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shanti Van MalderenNeuroplasticity and Movement Control Research Group, Rehabilitation Research Institute (REVAL), Hasselt University, Diepenbeek, Belgium.
Melina HehlNeuroplasticity and Movement Control Research Group, Rehabilitation Research Institute (REVAL), Hasselt University, Diepenbeek, Belgium.
Marten NuytsNeuroplasticity and Movement Control Research Group, Rehabilitation Research Institute (REVAL), Hasselt University, Diepenbeek, Belgium.
Stefanie VerstraelenNeuroplasticity and Movement Control Research Group, Rehabilitation Research Institute (REVAL), Hasselt University, Diepenbeek, Belgium.
Stephan P SwinnenKU Leuven, Leuven Brain Institute (LBI), Louvain, Belgium.
Koen CuypersNeuroplasticity and Movement Control Research Group, Rehabilitation Research Institute (REVAL), Hasselt University, Diepenbeek, Belgium. koen.cuypers@uhasselt.be.

Funding

Bijzonder Onderzoeksfonds KU Leuven PDMT2/24/077Bijzonder Onderzoeksfonds UHasselt, Belgium BOF21INCENT15Bijzonder Onderzoeksfonds UHasselt, Belgium BOF23INCENT18Fonds Wetenschappelijk Onderzoek 11F6921NFonds Wetenschappelijk Onderzoek 11L9322NFonds Wetenschappelijk Onderzoek G039821NFonds Wetenschappelijk Onderzoek,Belgium 11PBG24N
6 · The paper itself

Abstract

Motor performance declines with age, particularly affecting reaction time and proactive response inhibition. While cortical influences on age-related motor decline are well-documented, the cerebellum's role remains unclear. Cerebellar Brain Inhibition (CBI), which can be measured through dual-site transcranial magnetic stimulation (TMS), may provide insights into age-related changes in motor control. We aimed to (1) compare resting-state CBI between young and older adults, (2) investigate the relationship between CBI and upper limb motor performance, and (3) examine whether this relationship differs between age groups. Using dual-site TMS, resting-state CBI was assessed in young and older adults. Motor performance was evaluated using a task battery measuring simple and choice reaction times, and response inhibition. As expected, older adults exhibited significantly longer reaction times and reduced reactive inhibition with lower accuracy compared to younger adults. No significant differences in resting CBI were observed between age groups, and no association was found between CBI and motor performance outcomes. Despite clear age-related differences in motor performance, resting CBI revealed no difference between age groups and showed no association with motor control measures. These findings suggest that the effect of aging on dual-site TMS-derived cerebellar inhibition at rest and its association with motor performance might be limited. However, age-related cerebellar effects on motor control might manifest during task execution rather than at rest, highlighting the potential importance of investigating CBI modulation during motor performance in the context of aging.

Indexed as

AgingCerebellumNeural InhibitionPsychomotor PerformanceReaction TimeAdultAgedEvoked Potentials, MotorFemaleHumansMaleMiddle AgedTranscranial Magnetic StimulationYoung AdultAgingCerebellar brain inhibition (CBI)CerebellumDual-site TMSMotor controlTranscranial magnetic stimulation (TMS)

Identifiers

PMID40613946

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.