ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Comparative anti-cancer properties of carene isoforms induced apoptotic cell death in stomach and lung cancer cell lines.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Essential Oils as a Source of Anticancer Molecules: Critical Assessment of Current Evidence and Methodological Limitations-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Mechanism of Xiao-ai-fei Honey Ointment, a Traditional Uyghur Multi-Ingredient Medicinal Preparation, Against Cervical Cancer Based on Network Pharmacology and In Vitro Evaluation of Anti-Cancer Activity.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Looking at the fraction with Annexin V⁺ and propidium iodide⁺: insights into cell death types from preclinical studies in solid and haematological cancers.Apoptosis : an international journal on programmed cell death · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carene isoforms, particularly 3-carene, are naturally occurring bicyclic monoterpenes from Piper nigrum that exhibit promising anti-cancer properties due to their ability to induce apoptosis in malignant cells, but its mechanisms in gastric (AGS) and lung (H727) cancer cells remain unexplored. In this study, we investigated the effects of 3-carene on cell viability, anti-proliferative activity, and apoptosis in AGS and H727 cells treated with varying concentrations using MTT assays, light and fluorescence microscopy, flow cytometry, qRT-PCR, and molecular docking analyses. Pharmacokinetics and dynamics were assessed via ADMET analysis and simulations. Results demonstrated that 3-carene significantly reduced cell viability in both cell lines, with IC
Indexed as
Identifiers
40613941What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.