Evidence map›Paper›PMID 40613940›Full record

SynthesisNaunyn-Schmiedeberg's archives of pharmacology2025

Effectiveness and safety of perampanel in Lennox-Gastaut syndrome: a GRADE-assessed systematic review and meta-analysis.

Danisha Kumar, Haneen Sabet, Amr Elshahat, Mohamed El-Moslemani, Abdelfattah Arafa, Mahmoud G A Saleh, Sama Mahmoud Gamal, Abdallah Abbas

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Danisha Kumar *Dow University of Health Sciences, Karachi, Pakistan.
Haneen Sabet *Faculty of Medicine, Qena University, Qena, Egypt.
Amr ElshahatDepartment of Radiology, Yale University, New Haven, CT, United States.
Mohamed El-MoslemaniFaculty of Medicine, Al-Azhar University, Damietta, Egypt.
Abdelfattah ArafaFaculty of Medicine, Al-Azhar University, Damietta, Egypt.
Mahmoud G A SalehDepartment of Chemistry, College of Science, Northern Border University, Arar, Saudi Arabia.
Sama Mahmoud GamalFaculty of Medicine, Minia University, Minia, Egypt.
Abdallah AbbasFaculty of Medicine, Al-Azhar University, Damietta, Egypt. abdallah.abdelmoneam.abbas@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review and meta-analysis aims to evaluate the effectiveness and safety of perampanel (PER) as adjunctive therapy in patients with Lennox-Gastaut Syndrome (LGS), focusing on seizure outcomes and adverse events (AEs). A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and Cochrane CENTRAL up to June 2025. Clinical trials and observational studies assessing PER in LGS patients were included. Screening and data extraction were performed independently by two reviewers. Bias was assessed using RoB 2.0, ROBINS-I, and NOS tools. Meta-analyses were conducted using a random-effects model to estimate pooled incidence rates with 95% confidence intervals (CI). Heterogeneity was quantified using I

Indexed as

AnticonvulsantsLennox Gastaut SyndromeNitrilesPyridonesHumansSeizuresTreatment OutcomeAnticonvulsantsNitrilesperampanelPyridonesFycompaLennox-Gastaut syndromeMeta-analysisPerampanelSeizure reduction

Identifiers

PMID40613940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.