Evidence map›Paper›PMID 40613921›Full record

ArticleActa diabetologica2025

High-glucose stimulation triggers early transcription of a panel of proinflammatory mediators in rat Muller glia cells and retina primary explants.

Grazia Raffaella Tundo, Maria Grazia Atzori, Alessandra Boccaccini, Dario Cavaterra, Alessio Bocedi, Grazia Graziani, Stefano Marini, Pedro Miguel Lacal, Marika Villa, Flavia Pricci and 3 more

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Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Grazia Raffaella TundoDepartment of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy. grazia.raffaella.tundo@uniroma2.it.ORCID http://orcid.org/0000-0002-3866-3171
Maria Grazia AtzoriIRCCS, Fondazione Bietti, Rome, Italy.
Alessandra BoccacciniIRCCS, Fondazione Bietti, Rome, Italy.
Dario CavaterraDepartment of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, Italy.
Alessio BocediDepartment of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, Italy.
Grazia GrazianiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Stefano MariniDepartment of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
Pedro Miguel LacalLaboratory of Molecular Oncology, IDI-IRCCS, Rome, Italy.
Marika VillaDepartment of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, 00161, Italy.
Flavia PricciDepartment of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, 00161, Italy.
Monica VaranoIRCCS, Fondazione Bietti, Rome, Italy.
Mariacristina ParravanoIRCCS, Fondazione Bietti, Rome, Italy.
Diego SbardellaIRCCS, Fondazione Bietti, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several preclinical data support a main role of Muller glia, a type of retinal glial cells, in sensing hyperglycemia and, subsequently, acquiring a pro-inflammatory polarization during diabetic retinopathy onset and progression. Recently, we reported that stimulation of rat Muller glia cells (rMC1) with high glucose triggers a very early (< 15 min) and atypical signaling cascade, regulated by a Ca

Indexed as

Ependymoglial CellsGlucoseInflammation MediatorsNeurogliaRetinaAnimalsCells, CulturedDiabetic RetinopathyNF-kappa BRatsRats, Sprague-DawleyGlucoseInflammation MediatorsNF-kappa BDiabetic retinopathyIL-8InflammationNF-kBTranscripts

Identifiers

PMID40613921

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.