ArticleEuropean journal of nuclear medicine and molecular imaging2025
TSPO circadian pattern: a test-retest study of [
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeMitochondrial translocator protein 18 kDa (TSPO), expressed by brain cells involved in immunity, has been a positron emission tomography (PET) target in numerous neurological and psychiatric studies. TSPO PET ligand binding is influenced by the single nucleotide polymorphism rs6971, dividing the population into three groups: high-affinity binders (HAB), mixed-affinity binders (MAB), and low-affinity binders (LAB). Unlike most “second generation” TSPO ligands, [11C]ER176 allows imaging of even LAB. This study examines the yet unstudied test-retest reproducibility of [11C]ER176 binding in all TSPO genotypes.
methodsTwelve healthy participants were studied. Seven had two [11C]ER176 PET scans in the same day, morning and afternoon; five of these had a third PET scan on a separate morning. Five additional controls underwent two scans on separate mornings. Metabolite-corrected arterial input function (AIF) was used to calculate total distribution volume (VT) with a two-tissue compartment model.
resultsVT showed showed excellent reproducibility for scans performed at the same time of day: for AM scans, whole-brain variability, excluding an outlier, was 12.4 ± 6.0%. The intraclass correlation coefficient was excellent, at 0.92. However, VT showed a significant diurnal effect: [11C]ER176 parent SUV was higher in all subjects in AM compared to PM, while brain VT was lower in AM. HABs and MABs showed greater VT increases: whole-brain VT variability for AM versus PM was 8.5 ± 5.8% / 28.4 ± 4.5% / 28.5 ± 8.0% for LAB/MAB/HAB.
conclusion[11C]ER176 brain VT has good reproducibility across days for scans performed in the morning. However, VT shows diurnal effects, which must be accounted for in study design.
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