Evidence map›Paper›PMID 40613881›Full record

ArticleLangenbeck's archives of surgery2025

Predictive factors for the detection of occult metastases during staging laparoscopy in patients with gastric carcinoma and adenocarcinoma of the esophagogastric junction.

Felix von Bechtolsheim, Mareike Spindler, Veith Jungmann, Florian Oehme, Jürgen Weitz, Thilo Welsch, Benjamin Müssle

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PubMed Full text at PMC Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Felix von BechtolsheimDepartment of Visceral-, Thoracic and Vascular Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany. felix.bechtolsheim@ukdd.de.
Mareike SpindlerDepartment of Visceral-, Thoracic and Vascular Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Veith JungmannDepartment of Visceral-, Thoracic and Vascular Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Florian OehmeDepartment of Visceral-, Thoracic and Vascular Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Jürgen WeitzDepartment of Visceral-, Thoracic and Vascular Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Thilo WelschDepartment of Visceral-, Thoracic and Vascular Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Benjamin MüssleDepartment of Visceral-, Thoracic and Vascular Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPeritoneal metastasis can occur in all stages of gastric cancer (GC) and adenocarcinoma of the esophagogastric junction (AEG) but staging laparoscopy (SL) is recommended for advanced stages. This study aimed to evaluate predictive factors for the detection of further, previously unknown (occult) metastases during SL. MATERIALS &

methodsWe conducted a retrospective analysis of patients who underwent SL at our center between 2005 and 2018. Binary logistic regression analysis was used to identify risk factors for the occurrence of occult metastasis.

resultsA total of 232 patients were included in the analysis. Occult metastases were detected in 48 (20.7%) patients. Forty patients (17.2%) had peritoneal carcinomatosis, 4 (1.6%) had liver metastases, 3 (1.2%) had peritoneal and liver metastases, and 1 (0.4%) had omental metastases. Univariate analysis revealed that cT4 category; cM-positivity; WHO G3 grade; histology results revealing diffuse, mixed or undifferentiated Lauren subtypes; and signet ring cells were significant risk factors for occult metastasis. Multivariate analysis confirmed that cM-positive stage (OR: 17.672; 95% CI: 3.06 to 102.052; p = 0.001) and signet ring cell count (OR: 6.228; 95% CI: 1.151 to 33.716; p = 0.034) were independently associated with occult metastasis detection by SL.

conclusionOccult metastases are common in patients with GC or AEG who undergo SL. Histological evidence of signet ring cells should be considered a high-risk histology result and should be an independent indication for SL. Patients with positive cM staging might benefit from SL because of the high probability of further occult metastases.

Indexed as

AdenocarcinomaEsophageal NeoplasmsEsophagogastric JunctionLaparoscopyPeritoneal NeoplasmsStomach NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasm StagingRetrospective StudiesRisk FactorsAdenocarcinoma of the esophagogastric junctionGastric cancerOccult metastasisStagingStaging laparoscopy

Identifiers

PMID40613881
PMCPMC12227447

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