Evidence map›Paper›PMID 40613865›Full record

ArticleEuropean child & adolescent psychiatry2025

Exploring the association between gestational diabetes exposure and mental and behavioural disorders in offspring: the Finnish gestational diabetes (FinnGeDi) register-based study.

Jenni Kinnunen, Marja Vääräsmäki, Elina Keikkala, Sanna Mustaniemi, Eero Kajantie, Mika Gissler, Johan G Eriksson, Risto Kaaja, Hannele Laivuori, Hilkka Nikkinen

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In one paragraph

Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jenni KinnunenResearch Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, 90029, Finland. jenni.kinnunen@oulu.fi.
Marja VääräsmäkiResearch Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, 90029, Finland.
Elina KeikkalaResearch Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, 90029, Finland.
Sanna MustaniemiResearch Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, 90029, Finland.
Eero KajantieResearch Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, 90029, Finland.
Mika GisslerDepartment of Data Analytics, Finnish Institute for Health and Welfare, Helsinki, 00271, Finland.
Johan G ErikssonDepartment of General Practice and Primary Health Care, Helsinki University Hospital, University of Helsinki, Helsinki, 00014, Finland.
Risto KaajaInstitute of Clinical Medicine, Internal Medicine, Turku University Hospital, University of Turku, Turku, 20521, Finland.
Hannele LaivuoriMedical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Hilkka NikkinenResearch Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, 90029, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGestational diabetes mellitus (GDM) is associated with an increased risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in offspring. Our aim was to investigate whether GDM exposure is linked to wider spectrum of mental and behavioural disorders in offspring during the first 10 years of life.

methodsThis study included a population-based cohort of all women who delivered a singleton child in Finland in 2009, including 6,560 children exposed to maternal GDM and 51,770 control children. The main outcomes were the prevalence of mental and behavioural (including neurodevelopmental) disorders, and their subcategories, in study groups. Mother- and child-related covariates were adjusted for in the analyses.

resultsChildren exposed to GDM had a higher prevalence of mental and behavioural disorders (n = 1,010, 15.4%) compared with controls (n = 6,066, 11.7%; adjusted odds ratio (aOR): 1.18, 95% confidence interval [CI]: 1.09-1.28). In adjusted analyses, higher odds were observed only in boys (aOR: 1.25, 95% CI: 1.13-1.38). Specifically, GDM-exposed children had higher odds of behavioural disorders (aOR: 1.13, 95% CI: 1.02-1.25), developmental disorders (aOR: 1.14, 95% CI: 1.03-1.27) and behavioural disorders with physiological disturbances (aOR: 1.59, 95% CI: 1.16-2.18).

conclusionsChildren exposed to maternal GDM have a higher prevalence of mental and behavioural disorders compared with non-exposed children. Notably, GDM exposure was shown to be an independent risk factor for these disorders in boys only.

Indexed as

Autism Spectrum DisorderDiabetes, GestationalMental DisordersPrenatal Exposure Delayed EffectsAdultChildChild, PreschoolFemaleFinlandHumansInfantMalePregnancyPrevalenceRegistriesRisk FactorsBehavioural disorderGestational diabetesMental disorderNeurodevelopmental disorderOffspring

Identifiers

PMID40613865
PMCPMC12743089

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