Evidence map›Paper›PMID 40613731›Full record

ArticleNeuro-oncology2025

Point/Counterpoint: Intrathecal therapy for patients with leptomeningeal metastases from solid tumors.

Emilie Le Rhun, Barbara J O'Brien, Elena Pentsova, Matthias Preusser, Michael Weller, Adrienne Boire

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emilie Le RhunDepartment of Medical Oncology and Hematology, Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-9408-3278
Barbara J O'BrienDepartment of Neuro-Oncology, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-3149-5216
Elena PentsovaDepartment of Neurology, Brain Tumor Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-5854-0251
Matthias PreusserDivision of Oncology, Department of Medicine 1, Medical University, Vienna, Austria.
Michael WellerDepartment of Neurology, Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1748-174X
Adrienne BoireDepartment of Neurology, Brain Tumor Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-1188-7765

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Investigating Microenvironmental Interactions in Leptomeningeal MetastasisR01CA245499 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BOIRE, ADRIENNE A. · 2020 to 2024
$2.0M
National Cancer Institute Cancer Center P30-CA008NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA245499
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40613731
PMCPMC12526066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.