ArticleAge and ageing2025
Association between longitudinal trajectories of insomnia symptoms and subsequent cognitive decline: a prospective cohort study.
Article in Age and ageing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Association of Changes in Intrinsic Capacity With Cognitive Decline and Dementia: A Prospective Cohort Study.Neurology · 2026Article
- Immune cell subsets linking insomnia trajectories and incident cognitive impairment: a prospective cohort study.BMC medicine · 2026Article
- HK-ASAP study: protocol for a prospective cohort study on sleep quality, brain reserve and cognitive phenotypes in community-dwelling older adults.BMC geriatrics · 2026Article
- Altered brain glucose metabolism and connectivity in young adults with obstructive sleep apnea.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Prevalence and associated factors of insomnia among adults in Anhui Province, China.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies found that insomnia was an important risk factor for cognitive decline. However, previous studies only focused on baseline insomnia status, not taking into consideration the changes in insomnia status during follow-up. The study aimed to investigate the association between longitudinal trajectories of insomnia symptoms and subsequent cognitive decline.
methodsData were from 7727 adults aged ≥50 in the Health and Retirement Study. The exposure variable was insomnia symptoms, including difficulties in initiating and maintaining sleep, early morning awakening and non-restorative sleep. Insomnia status was assessed biennially from 2002 to 2006, and its change patterns were categorised as low, decreasing, increasing and high trajectory. Linear mixed effects models were used to evaluate the associations between trajectories of insomnia symptoms and consequent cognitive decline.
findingsCompared with participants experiencing sustained low insomnia symptoms, those experiencing decreasing insomnia symptoms (β = -0.013; 95% CI, -0.020 to -0.006), increasing insomnia symptoms (β = -0.018; 95% CI, -0.031 to -0.006) and sustained high insomnia symptoms (β = -0.025; 95% CI, -0.037 to -0.014) showed significantly accelerated global cognitive decline. In contrast, compared with participants experiencing sustained high insomnia symptoms, those with decreasing insomnia symptoms were significantly associated with decelerated global cognitive decline.
conclusionSustained high insomnia symptoms accelerates cognitive decline, while recovery of insomnia symptoms decelerates cognitive decline.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.