ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026
Evaluation of coagulation disorders and iron deficiency in women with heavy menstrual bleeding.
Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Call to action: identifying an underlying bleeding disorder in adolescents with heavy menstrual bleeding.Research and practice in thrombosis and haemostasis · 2026Review
- Evaluation of coagulation disorders and iron deficiency in women with heavy menstrual bleeding.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
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9 authors.
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Abstract
objectiveTo explore the incidence of congenital bleeding disorders (CBD), which may result in anemia, in a large cohort of women referred for heavy menstrual bleeding (HMB) in a specialized gynecologic unit.
methodsBetween January 2022 and January 2024, all women referred for HMB were screened. All benefited from Higham and ISTH-BAT scoring to assess the importance of blood loss. Gynecologic ultrasound was performed and antecedents were recorded. Standard coagulation tests, complete blood count, hemoglobin, ferritin, and C-reactive protein assays were performed.
resultsAmong 454 women, medical history disclosed eight cases of CBD (six von Willebrand diseases, one case of FVII deficiency and a CBD carrier). In the 446 others, coagulation tests identified 41 (9.2%) with von Willebrand Factor deficiency (VWF:GPAbR ≤ 50 IU/dL), very severe in three cases (0.7%). Overt anemia (hemoglobin ≤120 g/L) was found in 155 (34.7%) women, and low ferritin (<15 μg/L) in 191 (42.8%), with less than 30 μg/L for 324 patients (72.5%). Although the incidence of transfusions was limited, 341 (75.1%) of these women had received oral iron supplementation.
conclusionLaboratory screening in a large series of women with HMB disclosed potential CBD in almost 10% of them and overt or rampant anemia in at least 40%. These observations support the need to reinforce the detection and management of HMB.
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