Evidence map›Paper›PMID 40613567›Full record

ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging

Blood-Brain Barrier Dysfunction in Adults With Heart Failure.

Bhaswati Roy, Xingfeng Shao, Kamlesh J Jobanputra, Gregg C Fonarow, Danny J J Wang, Mary Woo, Rajesh Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bhaswati RoyDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, California, USA.
Xingfeng ShaoLaboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Kamlesh J JobanputraDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Gregg C FonarowDivision of Cardiology, University of California Los Angeles, Los Angeles, California, USA.
Danny J J WangLaboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Mary WooUCLA School of Nursing, University of California Los Angeles, Los Angeles, California, USA.
Rajesh KumarDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-5355-9586

Funding

Brain Metabolites and Temperature Changes in Obstructive Sleep Apnea AdultsR01HL174651 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Rajesh Kumar · 2024 to 2026
$2.1M
Blood-Brain Barrier Dysfunction and Brain Injury in Heart FailureR01NR014669 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, WOO, MARY ANN · 2014 to 2017
$1.9M
Central Autonomic Nervous System Regulation in Heart FailureR01NR013625 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, WOO, MARY ANN · 2012 to 2015
$1.7M
Brain Changes in Pediatric Obstructive Sleep ApneaR21HD102544 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH · 2021 to 2022
$429k
National Institute of Child Health and Human Development R21HD102544NHLBI NIH HHS R01 HL174651NHLBI NIH HHS R01HL174651NICHD NIH HHS R21 HD102544NIH HHSNINR NIH HHS R01 NR013625NINR NIH HHS R01NR-013625NINR NIH HHS R01 NR014669NINR NIH HHS R01NR-014669
6 · The paper itself

Abstract

background and purposeHeart failure (HF) patients show brain tissue injury in sites that mediate autonomic, cognitive, and mood dysfunctions that are linked with increased morbidity and mortality. The pathological mechanisms that may contribute to brain tissue injury in HF are unclear, but may include blood brain barrier (BBB) dysfunction.

methodsWe performed diffusion-weighted pseudo-continuous arterial spin labeling (DW-pCASL) in 27 HF and 59 controls to examine BBB, using a 3.0-Tesla MRI scanner, and assessed anxiety, depressive symptoms, and cognition. Using DW-pCASL data, arterial transit time (ATT, an index of large artery integrity) and water exchange rates across the BBB (Kw, an index of BBB function) maps were generated, normalized, smoothed, and compared between HF and controls, and correlated with cognition and mood.

resultsSignificantly increased mood deficits and reduced cognition appeared in HF over controls. Multiple brain areas, which are involved in mediating cognition and mood, showed altered Kw and ATT values in HF over controls. Increased Kw emerged in the insula, hippocampus, and cerebellum. ATT values decreased in the prefrontal cortices, cingulate, and cerebellum, and increased in a few sites in HF patients. Kw values from regions that are involved in mood and cognition functions showed significant associations with anxiety, depression, and cognition.

conclusionsHF patients show impaired BBB function and altered large artery integrity. BBB alterations may introduce neural damage to autonomic, mood, and cognitive regulatory areas, contributing to abnormal functions found in HF. The findings suggest a need to repair BBB function to rescue brain tissue and functions in this condition.

Indexed as

Blood-Brain BarrierDiffusion Magnetic Resonance ImagingHeart FailureAdultAgedBrainFemaleHumansMaleMiddle Agedanxietyarterial transient timeBDI‐IIcognitiondepressiondiffusion‐weighted pseudo‐continuous arterial spin labelingmagnetic resonance imagingwater exchange rate

Identifiers

PMID40613567
PMCPMC12236461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.