Trial reportJournal of cosmetic dermatology2025
Clinical Trial of Salmon Nasal Cartilage-Derived Proteoglycans on Human Facial Antiaging: A Randomized, Double-Blind, Placebo-Controlled Study.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinical Trial of Salmon Nasal Cartilage-Derived Proteoglycans on Human Facial Antiaging: A Randomized, Double-Blind, Placebo-Controlled Study.Journal of cosmetic dermatology · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProteoglycans (PGs) derived from salmon nasal cartilage are believed to have antiaging effects on the skin. However, comprehensive evaluations of their impact on various skin parameters in Chinese populations remain limited.
aimsThis study aims to evaluate the efficacy of oral PG supplementation in enhancing skin elasticity, hydration, and reducing roughness, wrinkles, and pigmentation in healthy adult volunteers.
methodsA 56-day randomized, double-blind, placebo-controlled trial was conducted involving 66 subjects aged 30-60. Subjects received a daily dose of 20 mg PG, and skin parameters were measured at baseline, 28 days, and 56 days. The study assessed skin elasticity, hydration, roughness, wrinkles, melanin content, and brown spots while monitoring for any adverse effects.
resultsSubjects receiving PG supplementation showed significant improvements in skin elasticity and hydration at both 28 days and 56 days (p < 0.001), with reductions in skin roughness and wrinkles (p < 0.001), and a significant decrease in melanin content and brown spots (p < 0.001). Compared to the placebo group, the PG group exhibited significant improvements in most skin parameters by 56 days, except in the wrinkle area percentage at the crow's feet, where no significant difference was observed. PG was well tolerated, with no adverse effects reported.
conclusionsOur findings suggest that daily oral intake of 20 mg PG effectively improves skin health by enhancing elasticity, hydration, and reducing signs of aging such as wrinkles and pigmentation.
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