Evidence map›Paper›PMID 40613445›Full record

ArticleMolecular nutrition & food research2025

Lactobacillus rhamnosus PB01 Oral Supplementation Alleviates Metabolic and Reproductive Dysfunctions in Type 1 Diabetic Male Rats.

Sihan Liu, Hiva Alipour, Malwina Ulanowska, Vladimir Zachar, Fereshteh Dardmeh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sihan LiuRegenerative Medicine, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark.ORCID 0009-0002-8457-7677
Hiva AlipourRegenerative Medicine, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark.ORCID 0000-0002-8500-4208
Malwina UlanowskaRegenerative Medicine, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark.ORCID 0009-0001-7548-8181
Vladimir ZacharRegenerative Medicine, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark.ORCID 0000-0002-5279-2690
Fereshteh DardmehRegenerative Medicine, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark.ORCID 0000-0002-2034-0147

Funding

Aalborg Universitet Probiotic Research InitiativeDepartment of Health Science and Technology, Faculty of Medicine, Aalborg University (Aalborg, Denmark)"Probiotic Research Initiative"
6 · The paper itself

Abstract

This study investigated the potential therapeutic effects of Lactobacillus rhamnosus PB01 supplementation on metabolic and reproductive dysfunctions in Type 1 diabetes mellitus (T1DM) rat model. Diabetic rats treated with L. rhamnosus PB01 (1 × 10⁹ CFU/day) showed significant improvements in metabolic and reproductive outcomes. Specifically, diabetes-induced weight loss was mitigated by approximately 13%, and the percentage of hyperactivated sperm in the treatment group was significantly 2.5 times higher than that of the diabetic controls. Additionally, testosterone levels were significantly elevated by 27%, further supporting the positive effects on reproductive health. The probiotic supplementation also led to improvements in insulin sensitivity, as evidenced by a 34.12% reduction in homeostasis model assessment index of insulin resistance (HOMA-IR). L. rhamnosus PB01 (DSM 14870) demonstrated potential as an adjunct therapy for managing T1DM-associated complications in the rat model, by improving insulin sensitivity, supporting weight management, and partially restoring diabetes-related fertility impairments, likely through modulation of hormonal pathways. However, further studies are needed to translate the results to humans and refine optimal dosing and supplementation duration for sustained benefits.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Lacticaseibacillus rhamnosusProbioticsAnimalsBlood GlucoseDietary SupplementsInsulin ResistanceMaleRatsRats, Sprague-DawleyTestosteroneWeight LossBlood GlucoseTestosteronediabetes mellitusmale infertilitymetabolic dysfunctionprobioticsreproductive hormone

Identifiers

PMID40613445
PMCPMC12410509

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.