Evidence map›Paper›PMID 40613379›Full record

ArticleFuture medicinal chemistry2025

Exploration of pyrazole-based pyridine-4-carbohydrazide derivatives as drug-resistant

Pardeep Kumar, Pradip Malik, Juned Ali, Deepanshi Saxena, Anuradha Singampalli, Rani Bandela, Sri Mounika Bellapukonda, Sugali Indravath Rajyalakshmi, Nagesh A Bhale, Amol G Dikundwar and 4 more

Abstract read
In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pardeep KumarDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Pradip MalikDivision of Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.
Juned AliDivision of Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.
Deepanshi SaxenaDivision of Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.
Anuradha SingampalliDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Rani BandelaDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Sri Mounika BellapukondaDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Sugali Indravath RajyalakshmiDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Nagesh A BhaleDepartment of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Amol G DikundwarDepartment of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Srinivas NanduriDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Arunava DasguptaDivision of Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.
Sidharth ChopraDivision of Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.
Venkata Madhavi YaddanapudiDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.ORCID 0000-0002-9813-8694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDevelopment of new effective drugs against multidrug resistant MATERIALS AND

methodsPyridine-4-carbohydrazide and substituted pyrazole aldehydes were used to synthesize target molecules (6a-r) which were evaluated against H

resultsAll compounds displayed excellent MICs in the range of 0.125-16

conclusionThe pyrazole clubbed with pyridine-4-carbohydrazide is a potential scaffold for further exploration as anti-TB agent.

Indexed as

Antitubercular AgentsDrug DesignHydrazinesMycobacterium tuberculosisPyrazolesPyridinesBacterial ProteinsHumansMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureQuantitative Structure-Activity RelationshipAntitubercular AgentsBacterial ProteinscarbohydrazideHydrazinespyrazolePyrazolesPyridinesAnti-tubercularcomputational toolsDrug-resistanceMD simulationsmolecular dockingpharmacokinetic propertiesPyrazolePyridine-4-carbohydrazide

Identifiers

PMID40613379
PMCPMC12296120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.