Evidence map›Paper›PMID 40613341›Full record

ArticleJournal of natural products2025

Synthesis and Absolute Configuration of the Sesquiterpene Lactone EPD, a Natural Product with Broad Antitumor Cell Activity via a Unique Mechanism of Action.

Caroline van Haaften, Jan Koek, Jaap D H van Eendenburg, Jim van Wiltenburg, Daphne J F Kluitmans, Yvonne Grobben, Guido J R Zaman, Wolter Ten Hoeve

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caroline van HaaftenDepartment of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-5031-9007
Jan KoekSymeres B.V., Kadijk 3, 9747 AT Groningen, The Netherlands.
Jaap D H van EendenburgDepartment of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-2498-621X
Jim van WiltenburgSymeres B.V., Kadijk 3, 9747 AT Groningen, The Netherlands.
Daphne J F KluitmansOncolines B.V., Kloosterstraat 9, 5349 AB Oss, The Netherlands.
Yvonne GrobbenOncolines B.V., Kloosterstraat 9, 5349 AB Oss, The Netherlands.
Guido J R ZamanOncolines B.V., Kloosterstraat 9, 5349 AB Oss, The Netherlands.ORCID 0000-0002-2477-8314
Wolter Ten HoeveSymeres B.V., Kadijk 3, 9747 AT Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sesquiterpene lactone eremophila-1(10),11(13)-dien-12,8β-olide (EPD), isolated from leaves of the

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicBiological ProductsLactonesSesquiterpenesCell Line, TumorDrug Screening Assays, AntitumorHumansMolecular StructurePlant LeavesAntineoplastic AgentsAntineoplastic Agents, PhytogenicBiological ProductsLactonesSesquiterpenes

Identifiers

PMID40613341
PMCPMC12305658

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.