Evidence map›Paper›PMID 40613081›Full record

ReviewToxicology reports2025

A review of the sidelined pollutant: Reviving the fight against heavy metal contamination in an era of emerging contaminants.

Odera R Umeh, Eziafakaego M Ibo, Chima I Eke, Hilda C Afeku-Amenyo, Duke U Ophori

Abstract readReview
In one paragraph

Review in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Salidroside in heavy metal toxicity: a mechanistic review of antioxidant, anti-inflammatory, and anti-apoptotic pathways.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  2. Combined Exposure to low Levels of CdBiological trace element research · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Odera R UmehDepartment of Earth and Environmental Studies, Montclair State University, Montclair, NJ 07043, USA.
Eziafakaego M IboDepartment of Environmental Management, Pan African University Life and Earth Sciences Institute, Ibadan, Oyo State, 200002, Nigeria.
Chima I EkeDepartment of Earth and Environmental Studies, Montclair State University, Montclair, NJ 07043, USA.
Hilda C Afeku-AmenyoDepartment of Earth and Environmental Studies, Montclair State University, Montclair, NJ 07043, USA.
Duke U OphoriDepartment of Earth and Environmental Studies, Montclair State University, Montclair, NJ 07043, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Groundwater contamination by heavy metals (HMs) remains a pressing global concern, presenting substantial risks to humans, animals, plants, and the environment. Although emerging pollutants have received increasing attention, the adverse impacts of HM have not been adequately resolved. This comprehensive review examines the current state of knowledge regarding HM in groundwater, addressing sources, global trends, transport, fate, sampling techniques, modeling, quality control, toxicity, treatment, sustainable measures, and vital research gaps. HM research has continued to dwindle since 2022, these chemicals infiltrate groundwater systems through various pathways, and their mobility and bioavailability are affected by changes in climate, geological heterogeneity, and chemical properties. Moreover, HM may interact with other emerging contaminants to enhance migration and toxicity; however, little or no research has been conducted to fully understand cocktail migration mechanisms and impacts in groundwater systems. Despite the existence of various treatment techniques, no single approach has been universally accepted as the sole solution for completely removing HM from drinking water systems. There is a pressing need for standardized and advanced sampling methods, stringent quality control measures, and the incorporation of cutting-edge technologies such as smart water sensors that can detect both charged and uncharged contaminants, and nanotechnology for effective management. The increasing toxicity of HM and their harmful effects on human health and ecosystems emphasize the need for continuous and novel research involving sustainable remedial strategies, as the battle against metal contamination in groundwater systems requires constant dedication, innovative research, and a shared commitment to protecting our environment.

Indexed as

Groundwater contaminationHeavy metalsSampling techniquesSustainable measuresToxicity assessmentTransport modeling

Identifiers

PMID40613081
PMCPMC12214268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.