Evidence map›Paper›PMID 40613039›Full record

ArticleJournal of clinical tuberculosis and other mycobacterial diseases2025

Medication adherence in patients with nontuberculous mycobacterial disease.

Arthur Lemson, Fleur Dijkhuizen, Ralf Stemkens, Arjan van Laarhoven, Reinout van Crevel, Jakko van Ingen, Rob Aarnoutse, Wouter Hoefsloot

Abstract read
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In one paragraph

Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arthur LemsonDepartment of Pulmonary Diseases, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.
Fleur DijkhuizenDepartment of Pulmonary Diseases, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.
Ralf StemkensDepartment of Pharmacy, Pharmacology and Toxicology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.
Arjan van LaarhovenDepartment of Internal Medicine and Radboud Community for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Reinout van CrevelDepartment of Internal Medicine and Radboud Community for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Jakko van IngenDepartment of Medical Microbiology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.
Rob AarnoutseDepartment of Pharmacy, Pharmacology and Toxicology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.
Wouter HoefslootDepartment of Pulmonary Diseases, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: We aimed to measure and understand medication adherence in patients with nontuberculous mycobacterial (NTM) disease. Methods: We enrolled adults with NTM disease receiving antimycobacterial treatment at Radboudumc, the Netherlands. Demographics and treatment outcomes were recorded, and medication adherence was assessed repeatedly. Adherence was measured using the Proportion of Days Covered (PDC) at 6 and 12 months, calculated from pharmacy records, and the 5-item Medication Adherence Report Scale (MARS-5). The Beliefs about Medicines Questionnaire (BMQ) explored reasons for (non)adherence. Results: Sixty-one participants were enrolled, with a mean age of 63.2 (±12.9) years. Forty-one (67 %) had pulmonary, and 20 (33 %) extrapulmonary NTM disease, with Conclusions: Medication adherence was high throughout the first year of NTM treatment, likely due to the perceived necessity of treatment and regular follow-up at our reference clinic.

Indexed as

5-item medication adherence report scaleBeliefs about medicines questionnaireMedication adherenceMycobacterium avium complexNontuberculous mycobacterial diseaseProportion of days covered

Identifiers

PMID40613039
PMCPMC12221756

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.