ArticlePhotonics research2025
Scattering correction through Fourier-domain intensity coupling in two-photon microscopy (2P-FOCUS).
Article in Photonics research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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3 authors.
Funding
Abstract
Light penetration depth in biological tissue is limited by tissue scattering. Correcting scattering becomes particularly challenging in scenarios with limited photon availability and when access to the transmission side of the scattering tissue is not possible. Here, we introduce, to our knowledge, a new two-photon microscopy system with Fourier-domain intensity coupling for scattering correction (2P-FOCUS). 2P-FOCUS corrects scattering by intensity modulation in the Fourier domain, leveraging the nonlinearity of multiple-beam interference and two-photon excitation, eliminating the need for a guide star, iterative optimization, or measuring transmission or reflection matrices. 2P-FOCUS uses random patterns to probe scattering properties, combined with a single-shot algorithm to rapidly generate the correction mask. 2P-FOCUS can also correct scattering beyond the limitation of the memory effect by automatically customizing correction masks for each subregion in a large field-of-view. We provide several proof-of-principle demonstrations here, including focusing and imaging through a bone sample, and imaging neurons and cerebral blood vessels in the mouse brain
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Registered trials
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