Evidence map›Paper›PMID 40612977›Full record

ArticleSurgical case reports2025

Curative Gastrectomy for Advanced Gastric Cancer in a Patient with Idiopathic Multicentric Castleman Disease: A Rare Case Report.

Ryohei Kawabata, Yuki Ushimaru, Hisashi Hara, Tomohira Takeoka, Yumiko Yasuhara, Terukazu Yoshihara, Akihiro Kitagawa, Takashi Takeda, Hideo Tomihara, Atsushi Naito and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ryohei KawabataDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.
Yuki UshimaruDepartment of Gastrointestinal Surgery, Osaka International Cancer Center, Osaka, Osaka, Japan.
Hisashi HaraDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.
Tomohira TakeokaDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.
Yumiko YasuharaDepartment of Pathology, Sakai City Medical Center, Sakai, Osaka, Japan.
Terukazu YoshiharaDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.
Akihiro KitagawaDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.
Takashi TakedaDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.
Hideo TomiharaDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.
Atsushi NaitoDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.
Masahiro MurakamiDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.
Shingo NouraDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.
Atsushi MiyamotoDepartment of Gastrointestinal Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIdiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder characterized by systemic inflammation and chronic immunosuppression. When solid malignancies such as gastric cancer arise in patients with iMCD, perioperative management becomes particularly challenging due to nutritional decline, reactive lymphadenopathy, and elevated surgical risk. CASE PRESENTATION: A 75-year-old man with a 26-year history of suspected iMCD treated with low-dose corticosteroids presented with epigastric discomfort. Endoscopy revealed a Borrmann type 2 lesion, and biopsy confirmed poorly differentiated adenocarcinoma. CT showed mild lymphadenopathy along the lesser curvature and left gastric artery, as well as systemic involvement. Inguinal node biopsy confirmed polyclonal plasma cell proliferation consistent with iMCD. The patient also met the Asian Working Group for Sarcopenia (AWGS) criteria for severe sarcopenia. A multidisciplinary team initiated preoperative respiratory rehabilitation, nutritional support, and resistance exercise therapy. Curative distal gastrectomy with D2 lymphadenectomy was performed without complications. Histopathology revealed pT2N0M0 (pStage IB) disease. Tocilizumab was started 3 months postoperatively, and the patient remains recurrence-free at 24 months.

conclusionsThis case highlights that, even in patients with long-standing iMCD and sarcopenia, carefully staged multimodal perioperative care-including accurate nodal evaluation and individualized systemic therapy-can enable successful curative surgery for advanced gastric cancer.

Indexed as

curative surgerygastric canceridiopathic multicentric Castleman diseaseimmunosuppressionlymphadenopathy

Identifiers

PMID40612977
PMCPMC12226139

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