Evidence map›Paper›PMID 40612965›Full record

ArticleRadiology case reports2025

Primary adrenal CD20-negative diffuse large B-cell lymphoma: Diagnostic and therapeutic challenges-A case report.

Mohammad Saad Salim Naviwala, Daania Shoaib, Reyan Hussain Shaikh, Romana Idrees, Muhammad Afzal

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PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohammad Saad Salim NaviwalaDepartment of Medical Oncology, Aga Khan University Hospital, Karachi, Pakistan.
Daania ShoaibDepartment of Medical Oncology, Aga Khan University Hospital, Karachi, Pakistan.
Reyan Hussain ShaikhMedical College, Aga Khan University, Karachi, Pakistan.
Romana IdreesDepartment of Pathology, Aga Khan University Hospital, Karachi, Pakistan.
Muhammad AfzalDepartment of Medical Oncology, Aga Khan University Hospital, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary adrenal lymphoma (PAL) is a rare, aggressive malignancy, often manifesting as bilateral adrenal masses with insufficiency. CD20-negative diffuse large B-cell lymphoma (DLBCL), a rarer variant, exhibits resistance to standard therapies and a poorer prognosis. We report a 60-year-old woman with bilateral adrenal masses diagnosed as CD20-negative unclassifiable DLBCL. Despite an initial response to CHOP chemotherapy, her disease progressed, necessitating salvage therapy with gemcitabine, cisplatin and dexamethasone. This case highlights the diagnostic complexity of CD20-negative DLBCL, particularly when presenting in rare extra-nodal sites such as the adrenal glands. Comprehensive immunohistochemical profiling and multidisciplinary management are crucial for accurate diagnosis and treatment planning. Given the poor prognosis and lack of standardized therapies, further research is needed to refine treatment strategies and improve outcomes for patients with CD20-negative DLBCL.

Indexed as

Adrenal insufficiencyCD20-negative DLBCLCHOP chemotherapyExtra-nodal lymphomaPrimary adrenal lymphoma

Identifiers

PMID40612965
PMCPMC12226089

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.