Evidence map›Paper›PMID 40612953›Full record

SynthesisFrontiers in immunology2025

Role of meningeal lymphatic vessels in brain homeostasis.

Meng-Ying Zhao, Chao-Yuan Ye, Yuan-Cheng Liu, Xiao-Ming Wang, Jun-Cai Fu, Xin-Yuan Liu, Rui Zhu, Yi-Zhao Li, Qing Tian

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Pathophysiology of chronic subdural hematoma-new insights.Therapeutic advances in neurological disorders · 2026
    Review
  9. Review
  10. Meningeal lymphatic dysfunction drives cognitive impairment after experimental subarachnoid hemorrhage.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meng-Ying ZhaoDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chao-Yuan YeDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuan-Cheng LiuDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiao-Ming WangDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jun-Cai FuDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xin-Yuan LiuDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Rui ZhuDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yi-Zhao LiDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qing TianDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meningeal lymphatic vessels (MLVs) form an important bridging structure between the brain and periphery, which drains cerebral metabolites in cerebrospinal fluid (CSF) and brain antigens to deep cervical lymph nodes (dCLNs), to maintain brain homeostasis. Increasing evidence reveals the importance of MLVs in brain ageing and various central nervous system (CNS) diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI), and multiple sclerosis (MS). Advances in research techniques have provided detailed insights into the structure and functions of MLVs, highlighting the therapeutic potential of targeting MLVs for related diseases. Here, we perform a systematic review of the features and functional regulation of MLVs, their associations with brain disorders, as well as some methodological advances in imaging of MLVs and the drainage pathway.

Indexed as

BrainHomeostasisLymphatic VesselsMeningesAnimalsHumansbrain homeostasiscerebrospinal fluid drainageimaging techniquemeningeal lymphatic vesselsneuroinflammationneurological disorders

Identifiers

PMID40612953
PMCPMC12221947

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.