ArticleFrontiers in neurology2025
Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Resting-State EEG Functional Connectivity and Independent Correlates of Cognitive Impairment in Patients with Atrial Fibrillation.Neuropsychiatric disease and treatment · 2026Article
- Workload analysis of pilot steep turn maneuvers using SR20 aircraft and EEG data.Frontiers in neuroscience · 2026Article
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Authors and funding
9 authors.
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Abstract
Aims: Atrial fibrillation (AF) is associated with cognitive decline, but the role of electroencephalography (EEG) in assessing cognitive dysfunction in AF patients is underexplored. Objective: This study investigated the relationship between resting-state EEG patterns and cognitive impairment in AF patients. Methods: We recruited 120 participants from the Affiliated Xuancheng Hospital, China (January 2023 to January 2024), categorizing them into healthy controls and AF patients. Resting-state EEG metrics, including power spectral density (PSD), functional connectivity (FC), cross-frequency coupling (CFC), and sample entropy (EnSA), were analyzed alongside the Montreal Cognitive Assessment (MoCA) scores. Mediation analysis explored EEG's role in the AF-cognitive decline relationship. Results: AF patients had significantly lower MoCA scores. PSD analysis showed increased δ and θ and decreased α and β activity. FC was reduced in the α and β bands but increased in localized θ and γ bands. CFC analysis revealed elevated θ-β and θ-γ phase-amplitude coupling (PAC), reduced β-γ PAC, and lower EnSA. EEG metrics were significantly correlated with MoCA scores, with θ-β PAC mediating cognitive decline. Conclusion: AF patients exhibit distinctive EEG changes, with θ-β PAC mediating cognitive impairment, suggesting the potential of resting-state EEG for cognitive assessment in AF patients.
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